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    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Posted By: ParRus
    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology
    10 weeks | English | MP4 | 960 x 540 | AVC ~319 kbps | 25 fps
    Vorbis | 128 Kbps | 48.0 KHz | 2 channels | 6-8 hours/week | 1.95 GB
    Genre: eLearning Video / Medicine, Biology

    This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials.
    What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?
    The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate "how" cell- level functions arise and "why" mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

    Topics covered include:


    Systems Level Reasoning: Bottom-Up and Top-Down Approaches for Complex Systems
    Cell Signaling Pathways: Molecules to Pathways, cAMP and MAP-kinase Pathways
    Signal Flow: Pathways to Networks
    The Actin Cytoskeleton: The Cell Motility Machine
    Mathematical Representations of Cell Biological Systems Time and Space
    Gathering Large Data Sets in Genomics and Proteomics
    Inferring Modules: Computational Analysis of Large Data Sets; Building Networks
    Small Scale Systems Biology Experiments
    Identifying Emergent Properties by Computation: Dynamical Models
    Emergent Properties: Ultrasensitivity, Bistability, Robustness and Fragility
    Modules to Functions: Control Systems
    Module-Boundaries: Sharp and Fuzzy, Interactions between Subcellular Modules
    Emergence of Cellular Functions from Subcellular Modules
    Systems Analysis of Complex Diseases
    Systems Pharmacology: Understanding Drug Action from a Systems Perspective

    also You can watch my other last: Coursera-posts

    General
    Unique ID : 47759214205739004142346488841852310337 (0x23EE170F373A7356E4714BA770365341)
    Complete name : Introduction to Systems Biology 3.1 7B Analyzing Large Data Sets (1915).mp4
    Format : WebM
    Format version : Version 2
    File size : 65.3 MiB
    Duration : 19mn 15s
    Overall bit rate mode : Variable
    Overall bit rate : 474 Kbps
    Writing application : Lavf55.10.100
    Writing library : Lavf55.10.100

    Video
    ID : 1
    Format : VP8
    Codec ID : V_VP8
    Duration : 19mn 15s
    Bit rate : 319 Kbps
    Width : 960 pixels
    Height : 540 pixels
    Display aspect ratio : 16:9
    Frame rate mode : Constant
    Frame rate : 25.000 fps
    Compression mode : Lossy
    Bits/(Pixel*Frame) : 0.025
    Stream size : 43.9 MiB (67%)
    Language : English
    Default : Yes
    Forced : No

    Audio
    ID : 2
    Format : Vorbis
    Format settings, Floor : 1
    Codec ID : A_VORBIS
    Duration : 19mn 15s
    Bit rate mode : Variable
    Bit rate : 128 Kbps
    Maximum bit rate : 700 Kbps
    Channel(s) : 2 channels
    Sampling rate : 48.0 KHz
    Compression mode : Lossy
    Delay relative to video : -43ms
    Stream size : 17.6 MiB (27%)
    Writing application : Lavc55.17.100
    Writing library : libVorbis (Schaufenugget) (20101101 (Schaufenugget))
    Language : English
    Default : Yes
    Forced : No
    Screenshots

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]

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    Coursera - Icahn School of Medicine - Introduction to Systems Biology [repost]