"Understanding Alzheimer's Disease" ed. by Inga Zerr

This book spans a variety of approaches to address the complex problem of Alzheimer´s disease - what is the cause, is there a single pathogenetic pathways or are there many of them, how can we address the whole clinical spectrum of the disease, how can the disease be diagnosed early and reliable and which perspectives we have for prevention and treatment.

The collection covers actual topics of interest for basic researcher, clinicians, epidemiologists and provides insight to various aspects of the disease.

Contents
Preface
Section 1 Pathogenesis
1 Structure and Function of the APP Intracellular Domain in Health and Disease
2 Mechanism of Alzheimer Amyloid p-Protein Precursor Localization to Membrane Lipid Rafts
3 The Amyloidogenic Pathway Meets the Reelin Signaling Cascade: A Cytoskeleton Bridge Between Neurodevelopment and Neurodegeneration
4 y-Secretase — Regulated Signaling and Alzheimer's Disease
5 Phosphorylation ofTau Protein Associated as a Protective Mechanism in the Presence of Toxic, C-Terminally Truncated Tau in Alzheimer's Disease
6 Pin1 Protects Against Alzheimer's Disease: One Goal. Multiple Mechanisms
7 Alzheimer Disease and Metabolism: Role of Cholesterol and Membrane Fluidity
Section 2 Diagnosis
8 Pre-Analytical and Analytical Critical Factors Influencing the High Variability of the Concentrations Levels of Alzheimer Disease Biomarkers in Cerebral Spinal Fluid
9 Candidate Bio-Markers of Alzheimer's Disease
10 Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease
Section 3 Therapy
11 Potential Therapeutic Strategies to Prevent the Progression of Alzheimer to Disease States
12 Animal Assisted Therapy and Activities in Alzheimer's Disease
Section 4 Epidemiology, Clinical Presentation and Prevention
13 Epidemiology of Alzheimer's Disease
14 Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer's Disease and Subcortical Vascular Dementia
15 Predicting Cognitive Decline in Alzheimer's Disease (AD): The Role of Clinical, Cognitive Characteristics and Biomarkers
16 Alzheimer's Disease and Diabetes
17 Prevention of Alzheimer's Disease: Intervention Studies