"Thalassemia and Other Hemolytic Anemias" ed. by Isam Al-Zwaini

This volume is dedicated to Hemolytic Anemias. Thalassemia is not a single disease; it is rather a group of hereditary disorders of the production of globulin chain of the hemoglobin. Throughout the world, thalassemia affects approximately 4.4 of every 10,000 live births. It represents a major social and emotional impact on the patient and his family and a major burden on health services where the prevalence is high.

Thalassemia is a very common disease first described by pediatrician Thomas Benton Cooley in 1925 who described it in a patient of Italian origin. At that time, it was designated as Cooley's anemia. George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Thalassa means "sea", and emia means "blood"), due to the fact that it is very common in the area of the Mediterranean Sea. This name is actually misleading because it can occur everywhere in the world.

Contents
1 Introductory Chapter: Thalassemia - An Overview
2 The Genetic Aspect of Thalassemia: From Diagnosis to Treatment
3 Emerging Techniques for Thalassemia Gene Detection
4 Invasive and Noninvasive Approaches in Prenatal Diagnosis of Thalassemias
5 Hypogonadism in Female Patients with Beta Thalassemia Major
6 Hepatitis C Virus in Thalassemia
7 Sickle Cell Disease: A Genetic Disorder of Beta-Globin
8 Direct Anti-Globulin Test and Clinical Diagnosis