"Sepsis: An Ongoing and Significant Challenge" ed. by Luciano Azevedo

This book provides several aspects of sepsis. Starting from the history of the disease and finishing with treatment of sepsis-associated organ dysfunctions, this book offers a wide scope of well-written and complete reviews concerning pathophysiological and therapeutic characteristics of sepsis. This book will provide a significant forum of discussion on the topic, and increase the awareness of the healthcare team regarding the important aspects of early recognition and treatment of this severe condition.

Sepsis is the major cause of death in non-cardiologic intensive care units around the world. Every year, billions of dollars are consumed in the treatment of sepsis and in research to understand its complex pathophysiology and therefore obtain future therapeutic opportunities. Despite the efforts of the scientists and medical practitioners, the mortality rates are still high and the incidence of sepsis is increasing.

Contents
Section 1 History of Sepsis
1 The History of Sepsis from Ancient Egypt to the XIX Century
Section 2 Sepsis Pathophysiology and Animal Studies
2 Experimental Sepsis Models
3 Sepsis, the Liver and the Gut
4 Nerve Growth Factor and Sepsis
5 Nicotinamide Phosphoribosyltransferase in Sepsis
6 Neural Reflex Control of Inflammation During Sepsis Syndromes
Section 3 Biomarkers in Sepsis
7 Early Detection of Sepsis. MOF and Outcome Prediction in Severely Traumatized Patients
8 New Biomarkers for Sepsis
9 The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation
10 Microdialysis Monitoring of Biomarkers for Early Recognition of Intestinal Ischemia
11 Challenges in the Diagnosis of Sepsis of the Neonate
12 Relevance of Procalcitonin for the Diagnosis of Early and Late-Onset Sepsis in Newborns
Section 4 Microbiology and Antimicrobial Therapy in Sepsis
13 Catheter-Related Bloodstream Infections in Critical Care
14 Beware of Unusual Organisms Masquerading as Skin Contaminants
15 Blood Culture Systems: From Patient to Result
16 Sepsis: Antimicrobial Therapy
Section 5 Sepsis in Specific Populations
17 Infections in Leukemia
Section 6 Treatment of Sepsis-Associated Dysfunctions
18 Continuous Renal Replacement Therapies in Patients with Severe Sepsis and Septic Shock
19 Induction Agents for Endotracheal Intubation in Severe Sepsis and Septic Shock