"The Pathogenesis of Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia: A continuing quest" by R. B. van Loenhout

The aim of this book was to improve understanding of the pathogenesis of pulmonary hypoplasia in CDH, to eventually aid in finding ways to modulate the natural course in a prenatally diagnosed child.

Essential elements required for a better understanding, such as how the different clinical problems relate to each other, are still lacking. A basic understanding of CDH together with pulmonary hypoplasia and PPHN is fundamental in our quest for new answers to protect these children from the sequelae of this anomaly.

Contents
1 - General Introduction & Outline
2 - Congenital diaphragmatic hernia: comparison of animal models and relevance to the human situation
3 - The pulmonary mesenchymal tissue layer is defective in an in vitro recombinant model of nitrofen-induced lung hypoplasia
4 - Apoptosis of Fibroblasts is Regulated by Epithelial Cells during Fetal Rat Lung Development in a Cell Recombinant Model
5 - Epithelial-Mesenchymal Transition in Nitrofen-induced Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia: A Pilot Study
6 - Postmortem Lung Biopsy for Obtaining Lung Tissue in Congenital Diaphragmatic Hernia
7 - The Von Hippel-Lindau Pathway in Diaphragmatic Defects
8 - General Discussion & Future Perspectives
9 - Summary & Samenvatting
ENGLISH SUMMARY
NEDERLANDSE SAMENVATTING
ABBREVIATIONS
ACKNOWLEDGEMENTS & DANKWOORD
CONTRIBUTING AUTHORS
TECHNICAL ASSISTANCE & SUPPORT
PHD PORTFOLIO
CURRICULUM VITAE AUCTORIS