"New Developments in the Pathogenesis of Rheumatoid Arthritis" ed. by Lazaros I. Sakkas

This volume is dedicated to the pathogenesis of rheumatoid arthritis (RA). MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA.


Contents
Preface
1 MicroRNAs in Rheumatoid Arthritis: From Pathogenesis to Clinical Utility
2 Role of MicroRNAs in Rheumatoid Arthritis
3 Cytokines in Rheumatoid Arthritis (RA)
4 BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets
5 The Gut Microbiota and Inflammation in Rheumatoid Arthritis
6 Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay
7 Synoviolin is a Novel Pathogenic Factor of Arthropathy and Chronic Inflammation
8 YKL‐40: The Search for New Biomarkers in Rheumatoid Arthritis