"Neurodegenerative Diseases" ed. by Uday Kishore

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. Approaches to therapeutic interventions have been presented. Students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression.

Contents
Preface
Section 1 Disease Mechanisms in Alzheimer's Disease
1 Alzheimer's Disease: A Clinical Perspective
2 Late-Onset Alzheimer's Disease: Risk Factors, Clinical Diagnosis and the Search for Bio markers
3 Role of Protein Aggregation in Neurodegenerative Diseases
4 Role of Oxidative Stress in A|3 Animal Model of Alzheimer's Disease: Vicious Circle of Apoptosis, Nitric Oxide and Age
5 Alterations of Mitochondria and Golgi Apparatus Are Related to Synaptic Pathology in Alzheimer's Disease
6 Caspases in Alzheimer's Disease
7 Brain Reserve Regulators in Alzheimer's Disease
8 Cholesterol and Alzheimer's Disease
Section 2 Therapeutic Aspects of Alzheimer
9 Emerging Therapeutic Strategies in Alzheimer's Disease
10 Dropping the BACE: Beta Secretase (BACEl) as an Alzheimer's Disease Intervention Target
11 QSAR Analysis of Purine-Type and Propafenone-Type Substrates of P-Glycoprotein Targeting p-Amyloid Clearance
12 Therapeutic Interventions in Alzheimer Disease
Section 3 Pathopysiological Aspects of Other Neurodegenerative Diseases
13 Other Dementias
14 The Role of Epigenetics in Neurodegenerative Diseases
15 Plasma Membrane Channels Formed by Connexins or Pannexins in Microglia: Possible Role in the Inflamed Brain
16 Influence of Obesity on Neurodegenerative Diseases
17 Electro-Physiological Approaches to Monitoring Neuro-Degenerative Diseases
18 Oxidative Changes and Possible Effects of Polymorphism of Antioxidant Enzymes in Neurodegenerative Disease
19 Intermediate Filaments in Neurodegenerative Diseases
20 Astrocytes Role in Parkinson: A Double-Edged Sword
21 Zinc and Neurodegenerative Diseases
22 Oligodendrocyte Metabolic Stress in Neurodegeneration
Section 4 Miscellaneous
23 Spinal Muscular Atrophy: Classification, Diagnosis, Background, Molecular Mechanism and Development of Therapeutics
24 Pharmacological Treatment of Acute Ischemic Stroke
25 Cognitive Dysfunction Syndrome in Senior Dogs