"Neglected Tropical Diseases New Advances" ed. by Márcia Aparecida Sperança

This volume is dedicated to tropical diseases. Advances in the understanding of neglected tropical diseases (NTDs) are inspiring the scientific community to investigate their eco-epidemiology and physiopathology, and to employ new biotechnological tools to fight against these devasting and complex infectious diseases which are associated with poverty.

The topics covered include the employment of digital PCR and next-generation sequencing strategies to diagnose NTDs in hosts and reservoirs in urban and rural areas, and new findings on insects’ reproductive biology that are enabling different vector control strategies. Eco-epidemiology of arboviruses in Latin America and physiopathology of Burili disease caused by Mycobacterium ulcerans are discussed, as is molecular characterization of Plasmodium vivax circumsporozoite protein (CSP) and its use in the epidemiology of malaria and vaccine development. Finally, the origin and pathogenic role of a serine protease inhibitor of Trypanosoma cruzi (TcISP2), the causative agent of Chagas disease, are explored.

Contents
1. Metabarcoding and Digital PCR (dPCR): Application in the Study of Neglected Tropical Diseases
2. Vector Control: Insights Arising from the Post-Genomics Findings on Insects’ Reproductive Biology
3. Neglected Arboviruses in Latin America
4. Mycobacterium ulcerans Disease and Host Immune Responses
5. Circumsporozoite Protein from Plasmodium vivax and Its Relationship to Human Malaria
6. Exploring the Evolutionary Origin and Biological Role of the Trypanosoma cruzi Ecotin-Like Molecule in Chagas’ Disease


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