"Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients... ed. by Terry Lichtor

This volume is dedicated to knowledge regarding the molecular biology of brain tumors, new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed.

A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included.
This new information will lead to efficacious treatment strategies for these tumors which remain a challenge.
In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Contents
Preface
1 Understanding Mitochondrial DNA in Brain Tumorigenesis
2 Systems Biology of Glioblastoma Multiforme
3 Tumor Microenvironment — Perivascular and Perinecrotic Niches
4 Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets
5 BMI Transcription Factor as a Novel Target for the Treatment of Brain Tumors
6 Metalloproteinases in Brain Tumors
7 Radiation-Induced Glioma
8 Radiation-Induced Brain Injury After Radiotherapy for Brain Tumor
9 Minimally Invasive but Maximally Effective Treatment of Anterior Skull Based Tumors — The Combination of Advanced Neuroendoscopy and Intraoperative Imaging with iMRI and O-Arm
10 Techniques to Improve the Extent of Brain Tumor Resection — Awake Speech and Motor Mapping, and Intraoperative MRI
11 Seizures in Children with Brain Tumours — Epidemiology, Significance, Management, and Outcomes
12 Imaging of Brain Tumours
13 Clinical Trials in Glioblastoma — Designs and Challenges
14 Clinical Presentation of Brain Tumors
15 Immune Modulation by Tumor-Derived Extracellular Vesicles in Glioblastoma
16 Immunology and Immunotherapy in Brain Tumors — Immune Failure and Potential Counteractions
17 Clinical Effects of Saireito for Patients with Advanced Stage Glioblastoma
18 Cannabidiol and Cancer — An Overview of the Preclinical Data