"The Mechanisms of DNA Replication" ed. by David Stuart

The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life.

Contents
Preface
Section 1 Machines that Drive DNA Replication
1 Pulling the Trigger to Fire Origins of DNA Replication
2 Replicative Helicases as the Central Organizing Motor Proteins in the Molecular Machines of the Elongating Eukaryotic Replication Fork
3 The MCM and RecQ Helicase Families: Ancient Roles in DNA Replication and Genomic Stability Lead to Distinct Roles in Human Disease
4 DNA Replication in Archaea, the Third Domain of Life
5 Proposal for a Minimal DNAAuto-Replicative System
6 Extending the Interaction Repertoire of FHAand BRCT Domains
7 Intrinsically Disoredered Proteins in Replication Process
Section 2 Mechanisms that Protect Chromosome Integrity During DNA Replication
8 Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point
9 The Role of WRN Helicase/Exonuclease in DNA Replication
Section 3 Replication of Organellar Chromosomes
10 Replicational Mutation Gradients, Dipole Moments. Nearest Neighbour Effects and DNA Polymerase Gamma Fidelity in Human Mitochondrial Genomes
11 The Plant and Protist Organellar DNA Replication Enzyme POP Showing Up in Place of DNA Polymerase Gamma May Be a Suitable Antiprotozoal Drug Target
Section 4 Chromatin and Epigenetic Influences on DNA Replication
12 Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family
13 The Mechanisms of Epigenetic Modifications During DNA Replication
14 Chromatin Damage Patterns Shift According to Eu/Heterochromatin Replication
15 A Histone Cycle
16 Replicating - DNA in the Refractory Chromatin Environment
Section 5 Telomeres
17 Telomeres: Their Structure and Maintenance
18 Telomere Shortening Mechanisms

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