"Macrophage Activation: Biology and Disease" ed. by Khalid Hussain Bhat

This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.


Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge.

Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge.

Contents
1.Macrophages: The Potent Immunoregulatory Innate Immune Cells
2.The Pivotal Role of Macrophages in Metabolic Distress
3.Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens
4.Macrophages in the Pathogenesis of Leprosy
5.Macrophage Polarization Is Decisive for Chronic Bacterial Infection-Induced Carcinogenesis
6.Polarization of Tumor-Associated Macrophages by Chinese Medicine Intervention: Mechanisms and Applications