Leptin and Leptin Antagonists by Arieh Gertler
Leptin and Leptin Antagonists by Arieh Gertler
Publisher: Landes Bioscience (February 2009) | ISBN: 1587063204 | Pages: 185 | PDF | 2.6 MB
Publisher: Landes Bioscience (February 2009) | ISBN: 1587063204 | Pages: 185 | PDF | 2.6 MB
Th e discovery of leptin, the obese (ob) gene product which is not expressed as a functional protein in ob/ob mice, focused the scientifi c community’s attention on its role as an anorexic hormone involved in the negative regulation of food intake. Almost 14 years aft er this breakthrough discovery and over 14,000 leptin-related publications later, leptin is now known to participate in a wide range of biological functions that include, in addition to its early envisaged function as an adipostat, glucose metabolism, glucocorticoid synthesis, CD4+ T-lymphocyte proliferation, cytokine secretion, phagocytosis, hypothalamic-pituitary-adrenal axis regulation, reproduction, cardiovascular pathology, bone formation, apoptosis and angiogenesis.