Human Genetics

Genetic Disorders, Pedigree Analysis

What you'll learn

Define Genetics and human Genetics

Define and explain the different types of genetic disorders along with examples

The students will have a good knowledge of pedigree analysis

The student will be able to draw and explain the pedigree of different human genetic disorders

Requirements

Basic knowledge of Biology especially about DNA

Description

Human genetics is a branch of biology that studies how human traits are determined and passed down among generations. Explore this exciting field to better understand how your genes help shape your traits and health. Study of the inheritance of characteristics/traits from one generation to another i.e. from parents to children. This inheritance in humans does not differ in any fundamental way from that in other organisms. Genetic disorders; often are described in terms of the chromosome that contains the gene that is changed in people who have the disorder. If the gene is on one of the autosomes (first 22 pairs of chromosomes), the genetic disorder is called an autosomal condition. If the gene is on the X chromosome, called an X-linked condition. Human genetics research generates knowledge/data to improve individual and community healthThe research can also reveal information about individual susceptibility to genetic disease and hence about the individual’s future health. It has been long known that drug toxicity and efficacy have a genetic component and hence such data are becoming increasingly important in drug development. It is very important in promoting health and preventing disease. The study of human genetics can have important medical, social, and legal impactsThis course is designed to give a basic understanding of the important concept in Human Genetics. The course will start with an introductory video along with the importance of Human Genetics. The focus of the course is to understand the different types of genetic disorders along with important examples; Autosomal Dominant, Autosomal Recessive, X-Linked Dominant, and X-Linked Recessive. The course will then focus on the details of Pedigree analysis of different types of genetic disorders as mentioned above.

Overview

Section 1: Introduction

Lecture 1 Introduction

Section 2: Pattern of transmission of single gene trait

Lecture 2 Pattern of transmission of single gene trait: Part 1

Lecture 3 Part 2

Section 3: Autosomal Dominant Genetic Disorders

Lecture 4 Huntington's disease; Part 1

Lecture 5 Huntington's disease; Part 2

Lecture 6 Huntington's disease; Part 3

Section 4: Autosomal Recessive Genetic Disorders

Lecture 7 Sickle Cell Anemia; Part 1

Lecture 8 Sickle Cell Anemia; Part 2

Lecture 9 Sickle Cell Anemia; Part 3

Lecture 10 Sickle Cell Anemia; Part 4

Lecture 11 Introduction to Cystic Fibrosis and CFTR

Lecture 12 Genetics of Cystic Fibrosis

Lecture 13 Diagnosis of Cystic Fibrosis

Lecture 14 Symptoms of Cystic Fibrosis

Lecture 15 Treatment and Prevention of Cystic Fibrosis

Section 5: X Linked Genetic Disorders

Lecture 16 X Linked Dominant Traits; Alport Syndrome

Lecture 17 X Linked Recessive Traits; Hemophilia A

Lecture 18 X Linked Recessive Traits; Hemophilia B

Section 6: Hemostatis

Lecture 19 Introduction to Hemostasis and Composition of Blood

Lecture 20 The Structure, function and composition of Platelets

Lecture 21 Primary Hemostasis; Vasoconstriction

Lecture 22 Primary Hemostasis; Platelets Adhesion

Lecture 23 Primary Hemostasis; Platelets Activation and Degranulation

Lecture 24 Secondary Hemostasis; Intrinsic Pathway

Lecture 25 Secondary Hemostasis; Extrinsic Pathway

Section 7: Pedigree Analysis

Lecture 26 Basics of Pedigree Analysis

Lecture 27 Degree of Relationahip

Lecture 28 Pedigree Analysis of Autosomal Dominant Disorders

Lecture 29 Pedigree Analysis of Autosomal Dominant Disorders; Part 2

Lecture 30 Pedigree Analysis of Autosomal Recessive Disorder

Lecture 31 Pedigree Analysis of X-Linked Dominant Dosorder

Lecture 32 Pedigree Analysis of X-Linked Recessive Disorder

Undergraduate biology students