"Infectious Process and Sepsis" ed. by Vincenzo Neri

This book attempts to answer these questions. Chapters cover such topics as surgical infections, microbiota therapy in sepsis, cytokines for host immune response, and the role of serum amyloid A in the acute phase of sepsis.

Sepsis is a very complex clinical condition that can be considered the central point of the infectious process: the arrival point in the evolution of a localized septic outbreak that has caused a systemic inflammatory reaction. In the clinical setting two important questions regarding the transition from local inflammation, with beneficial effect, to systemic inflammatory disease, with deleterious results, remain unanswered. First, why does the transition from local to systemic disease only occur in some subjects? Second, how long does this transition take?


Contents
1.Introductory Chapter: Surgical Infections
2.Immunoparalysis in Septic Shock Patients
3.Microbiota-Oriented Diagnostics and Therapy in Sepsis: Utopia or Necessity?
4.Cytokine Gene Polymorphism and Sepsis
5.Hemostatic Aspect of Sepsis
6.The Invariant Peptide Clusters of Serum Amyloid A Are Humoral Checkpoints for Vital Innate Functions as Probed by Monoclonal Antibodies, Including in Sepsis: Induction by Febrile Temperatures and Path of Discoveries