"Gene Expression and Regulation in Mammalian Cells: Transcription Toward the Establishment of Novel Therapeutics" ed. by Allan

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists.

Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Contents
1 Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity
2 Control of Ribosomal RNA Transcription by Nutrients
3 DNA Methylation in Mammalian Cells
4 Histone Chaperones Regulate Mammalian Gene Expression
5 Epigenetic Factors: Key Regulators Targeted in Cancers
6 Hydroxymethylation Influences on Intestinal Epithelial Cells in Health and Disease
7 The Key Role of E2F in Tumor Suppression through Specific Regulation of Tumor Suppressor Genes in Response to Oncogenic Changes
8 Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease
9 Regulatory Functions of Paxl and Pax9 in Mammalian Cells
10 The Hypoxia-Inducible Factor-la in Angiogenesis and Cancer: Insights from the Drosophila Model
11 Manipulation and Study of Gene Expression in Neurotoxin-Treated Neuronal PC12 and SH-SY5Y Cells for In Vitro Studies of Parkinson's Disease
12 Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype
13 Passenger or Driver: Can Gene Expression Profiling Tell Us Anything about LINE-1 in Cancer?
14 Viral Modulation of Host Translation and Implications for Vaccine Development