"Gastrointestinal Stromal Tumour" ed. by Raimundas Lunevicius

This book provides summarised and case-based knowledge on current management of gastrointestinal and extragastrointestinal stromal tumours. The book may be considered as a worthwhile timely addition to clinical science dissemination, medical education, further basic and clinical research.

Almost 30 years have gone by since the postulation that GISTs derive from mesenchymal stem elements, and only 15 years have gone by since the definitive detection of origin of GISTs. Research in the last decade was more focused upon the justification of imatinib mezylate therapy in GISTs and clarification why a secondary resistance that occurred during the kinase inhibitors therapy.
The era of therapy for GISTs, targeting the primary activating mutations in the KIT proto-oncogene; is being proclaimed as bringing the message of special importance to the pathologist role in multidisciplinary team that are responsible for treating patients with locally advanced or metastatic GIST.

Contents
Preface
1 GISTs: From the History to the Tailored Therapy
2 Treatment Options for Gastrointestinal Stromal Tumors
3 Molecularly Targeted Therapy: Imatinib and Beyond
4 Surgical Treatment of Gastrointestinal Stromal Tumors (GISTs)
5 The Role of the Surgeon in Multidisciplinary Approach to Gastrointestinal Stromal Tumors
6 Gastrointestinal Stromal Tumor of the Rectovaginal Septum, a Diagnosis Challenge
7 The Significance of the Ki-67 Labeling Index, the Expression of c-kit, p53, and bcl-2, and the Apoptotic Count on the Prognosis of Gastrointestinal Stromal Tumor