Fundamentals of Pediatric Drug Dosing

Editors: Mahmood, Iftekhar, Burckart, Gilbert (Eds.)
Collects information on physiological, pharmacological, and pharmacokinetic differences between the pediatric population and adults, providing a comprehensive overview to the reader
Discusses the importance and complexities of clinical trial design in pediatrics
Provides the reader with different aspects of modeling and simulation in pediatrics, which can be applied during drug development
Describes the principles and application of allometry to the prediction of PK parameters as well as dose selection in pediatric population

Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource.
With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not ‘small adults’, and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.

Number of Pages
VIII, 146
Number of Illustrations and Tables
12 illustrations in colour
Topics
Pediatrics
Pharmacotherapy
General Practice / Family Medicine



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