"Experimental Animal Models of Human Diseases: An Effective Therapeutic Strategy" ed. by Bartholomew Ibeh

This book is a collection of expert essays on animal models of human diseases of global interest. A objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases.

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery.
Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates.

An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Contents
1 Introductory Chapter: Animal Models for Human Diseases, a Major Contributor to Modern Medicine
2 Animal Models of Diabetic Retinopathy (Part 1)
3 Animal Models of Diabetic Retinopathy (Part 2)
4 Animal Models of Central Diabetes Insipidus: Oxytocin and Low-Sodium Diets as Complementary Treatments
5 Animal Models of Obesity Characterized by Non-alcoholic Fatty Liver Disease (NAFLD)
6 Rodent Models of Obesity and Diabetes
7 Animal Models of Double Incontinence: "Fecal and Urinary"
8 Relevance of the CDE and DDC Mouse Models to Study Ductular Reaction in Chronic Human Liver Diseases
9 Experimental Animal Models of HIV/AIDS for Vaccine Trials
10 Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases
11 Use of Animal Models in the Study of Colitis
12 Evaluation of Animal Models Suitable for Hair Research and Regeneration
13 Animal Models of Rheumatoid Arthritis
14 Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System
15 Studying Side Effects of Tyrosine Kinase Inhibitors in a Juvenile Rat Model with Focus on Skeletal Remodeling
16 Animal Models of Fetal Medicine and Obstetrics
17 Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model