"Drug Discovery and Development: New Advances" ted. by Vishwanath Gaitonde, Partha Karmakar, Ashit Trivedi

Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. The book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields.


Contents
1.Introductory Chapter: The Modern-Day Drug Discovery
2.Past, Present, and Future of Molecular Docking
3.Molecular Docking in Modern Drug Discovery: Principles and Recent Applications
4.Computational Deorphaning of Mycobacterium tuberculosis Targets
5.Revisiting Pharmacokinetics and Pharmacogenetics of Methadone in Healthy Volunteers
6.ADME Profiling in Drug Discovery and a New Path Paved on Silica
7.Successive Drug Therapy for a Very Rare Autosomal Diseases
8.Challenges and New Frontiers in the Paediatric Drug Discovery and Development