"Dermal Absorption and Toxicity Assessment" by Michael S. Roberts, Kenneth A. Walters

Written by internationally recognized experts in the field, this revised and updated Edition coverers the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity

The book supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections.

Contents
Preface to the Second Edition
Preface from the First Edition
Contributors
Introduction
1. Human Skin Morphology and Dermal Absorption
2. Animal Skin Morphology and Dermal Absorption
Part I: Skin Barrier Properties and Absorption
3. The Physical Structure of the Skin Barrier
4. Morphology of Epidermal Lipids
5. Stratum Corneum as a Biosensor
6. Cutaneous Metabolism
7. Formulation Issues
Part II: Measurement of Skin Absorption
8. Interpretation of In Vitro Skin Absorption Studies of Lipophilic Chemicals
9. Use of Skin Equivalents for Dermal Absorption and Toxicity
10. Skin Absorption as Studied by Spectroscopic Methods
Part III: Modeling of Dermal Absorption and Risk Assessment
11. Physiologically Based Pharmacokinetics and Pharmacodynamics of Skin
12. Beyond Stratum Corneum
13. Biophysical Models for Skin Transport and Absorption
14. Mathematical Models for Different Exposure Conditions
15. Modeling Skin Permeability in Risk Assessment
16. In Vitro-In Vivo Correlations in Transdermal Drug Delivery
17. Estimation of Subsequent Systemic Exposure—Physiological Models
18. RISKOFDERM: Predictions Based on In Vivo Factors
Part IV: Skin Toxicity and Prevention
19. Quantitative Structure-Activity Relationships for Skin Corrosivity and Sensitization
20. Allergic Contact Dermatitis
21. Irritancy of Topical Chemicals in Transdermal Drug Delivery Systems
22. Photosensitivity Induced by Exogenous Agents: Phototoxicity and Photoallergy
23. Systemic Toxicity Caused by Absorption of Drugs and Chemicals Through Skin
24. Solvent and Vehicle Effects on the Skin
Part V: Regulatory Issues
25. United States Environmental Protection Agency Perspectives on Skin Absorption and Exposure
26. Dermal Absorption of Chemicals: Some Australian Regulatory Considerations
27. International Perspectives in Dermal Absorption
28. Structure-Activity Relationships and Prediction of Photoallergic and Phototoxic Potential
29. Potential Regulatory Use of (Q)SARs to Develop Dermal Irritation and Corrosion Assessment Strategies
30. Development of (Q)SARs for Dermal Irritation and Corrosion Assessment Using European Union New Chemicals Notification Data
31. Regulatory Assessment of Skin Sensitization
32. Assessment of Topical Bioequivalence Using Microdialysis and Other Techniques
33. An Industry Perspective of Topical Dermal Bioequivalence
Part VI: Specific Examples of Absorption
34. Dermal Absorption of Chemical Contaminants from Soil
35. Percutaneous Absorption of Pesticides
36. Bathing Water: Percutaneous Absorption of Water Contaminants
37. Percutaneous Absorption of Prodrugs and Soft Drugs
38. Skin Penetration of Cosmetic Ingredients and Contaminants
39. Percutaneous Absorption of Hair Dyes
40. Dermal Absorption of Fragrance Materials