"Cytoskeleton: Structure, Dynamics, Function and Disease" ed. by Jose C. Jimenez-Lopez

This book provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases.

The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking).

The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.


Contents
Preface
1 Reorganization of Vegetal Cortex Microtubules and Its Role in Axis Induction in the Early Vertebrate Embryo
2 Actin-Microtubule Interaction in Plants
3 Morphological and Functional Aspects of Cytoskeleton of Trypanosomatids
4 The Interplay between Cytoskeleton and Calcium Dynamics
5 Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions
6 Dystrophin–Glycoprotein Complex in Blood Cells
7 Biophysics of Fish Sperm Flagellar Movement: Present Knowledge and Original Directions
8 Cytoskeleton Rearrangements during the Execution Phase of Apoptosis
9 How are Dynamic Microtubules Stably Tethered to Human Chromosomes?
10 Muscle Fibers Lacking Desmin in the Extraocular Muscles: A Paradigm Shift
11 The Actomyosin Network and Cellular Motility: A S100A4 Regulatory View into the Process
12 Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity
13 Acting on Actin During Bacterial Infection
14 Heterotrimeric G Proteins and the Regulation of Microtubule Assembly
15 Novel Insights into the Role of the Cytoskeleton in Cancer
16 Targeting the Cytoskeleton with Plant-Bioactive Compounds in Cancer Therapy