"Chemistry and Biological Activity of Steroids" ed. by Jorge António Ribeiro Salvador, Maria Manuel Cruz Silva
"Chemistry and Biological Activity of Steroids" ed. by Jorge António Ribeiro Salvador, Maria Manuel Cruz Silva
ITExLi | 2020 | ISBN: 1789855160 9781789855166 1789855152 9781789855159 1789856086 9781789856088 | 127 pages | PDF | 7 MB
ITExLi | 2020 | ISBN: 1789855160 9781789855166 1789855152 9781789855159 1789856086 9781789856088 | 127 pages | PDF | 7 MB
This volume aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book.
The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. The diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.
Contents
1.Introductory Chapter: Chemistry and Biological Activity of Steroids - Scope and Overview
2.Biotransformation of Steroids Using Different Microorganisms
3.Estrone Sulfatase Inhibitors as New Anticancer Agents
4.Control of Liver Gene Expression by Sex Steroids and Growth Hormone Interplay
5.Role of Androgens in Cardiovascular Diseases in Men: A Comprehensive Review
6.Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation
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