"Challenges in Parkinson's Disease" ed. by Jolanta Dorszewska and Wojciech Kozubski

This book is a sum up of knowledge on the genetic factors and neuronal death mechanisms induced by excitotoxic and inflammatory agents. The authors summarize the pathophysiology observed both in patients with Parkinson's disease and in experimental models.

The book contains the latest views on drug therapy used in the treatment of parkinsonism and other therapeutic approaches for Parkinson's disease.

Parkinson's disease is a common neurological disease and affects 2% population of more than 65 years of age and 5% more than 85 years of age. Pathomechanism of this disease is still not fully understood.

Contents
Preface
1 Introductory Chapter - Genetic and Biochemical Factors in Parkinson’s Disease
2 Genetics of Parkinson’s Disease: The Role of Copy Number Variations
3 Mechanisms for Neuronal Cell Death in Parkinson’s Disease: Pathological Cross Talks Between Epigenetics and Various Signalling Pathways
4 Inflammation: Role in Parkinson's Disease and Target for Therapy
5 Chronic Inflammation Connects the Development of Parkinson’s Disease and Cancer
6 Is Chronic Systemic Inflammation a Determinant Factor in Developing Parkinson’s Disease?
7 Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease
8 Cognitive Impairment in Parkinson’s Disease: Historical Review, Past, and Present
9 Brain Network Metabolic Changes in Patients with Parkinsonian Tremors
10 Animal Models of Parkinson’s Disease
11 Understanding Pathophysiology of Sporadic Parkinson's Disease in Drosophila Model: Potential Opportunities and Notable Limitations
12 Pharmacotherapeutic Challenges in Parkinson’s Disease Inpatients
13 Clinical and Experimental Cell Therapy in Parkinson’s Disease
14 Cell-Based Therapies for Parkinson’s Disease: Preclinical and Clinical Perspectives
15 Stem Cell Therapy for Parkinson's Disease
16 Surgical Therapy of Parkinson's Disease
17 Neuro-Ophthalmologic Evaluation as a Biomarker for Diagnosis and Progression in Parkinson Disease
18 Possible Treatments of Atypical Parkinsonism
19 The Role of Nurses in Parkinson's Disease