Cell Signaling; How Our Body Cells Coordinates

Cellular Signaling

What you'll learn
Understand the basic principles of signal transduction mechanisms
Understand the different types of signaling
Understand the different types of Kinases and their role and importance in signaling pathways
Understand the different types of ligands and receptors and their role and importance in signaling pathways
Understand Mating of haploid yeast cell (an example from unicellular world)
Nonreceptor Tyrosine Kinase Mediated Cell Signaling; The Src and its Signaling Pathway and Serine / Threonine Kinase Mediated Cell Signaling
Understand Karyopherin; group of proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell
Understand Neuronal Signaling
Cell Cycle and its importance the regulated cell division and Cancer
Requirements
Basics of Biology
Description
Birth, life and death involve the integration of a complex array of biosignals that living cells sense and process to respond and adapt to modifications of their environment. The signals that are sent and received by cells during their whole existence are essential for the harmonious development of tissues, organs and bodies. They also govern movement, thought and behavior. It is now well established that cells do not behave as selfish entities but rather tend to form “microsocieties” whose proper functioning requires a precise coordination of emission and reception of signals. Understanding the molecular basis for the coordinated biological signals will provide a better insight into the processes governing fundamental biological activities such as growth, differentiation, and quiescence.Cell signaling underlies critical cellular decisions such as development, cell growth and division, differentiation, migration, apoptosis, and it essentially provides the coordination required for the functionality of multicellular organismsDysfunctioning of the networks is associated with pathological situations that can range from abnormal proliferation to death.Recently it has become apparent that a number of human diseases, among them such diverse disorders as cholera, hyperthyroidism and certain types of diabetes, arise from a common mechanism: faulty communication among cells.Cancer cells have constant activation of signaling pathways instructing the cells to grow and divide. This often occurs because of changes (mutations) in receptors, protein kinases or transcription factors that keep the proteins an active state.Some immunodeficiencies occur because immune cells lack the receptors for ligands that instruct immune cells to divide and develop, or lack the specific kinases that transmit these signals.Cell communication is also essential for plant development. Plasmodesmata are regulatable channels which support macromolecular transport between neighbouring cells. Signaling molecules circulate within the plasmodesmata and their transport can be altered in pathological conditions, such as viral infection.

Overview

Section 1: Introduction

Lecture 1 Introduction

Lecture 2 Applications of Cell Signaling/ Importance of Cell Signaling

Lecture 3 Why living organisms need a signaling system

Lecture 4 Types of Cell Signaling

Lecture 5 Ligands and Receptors; Part 1

Lecture 6 Ligands and Receptors; Part 2

Lecture 7 Mating of haploid yeast cell; Example of cell signaling from unicellular world

Lecture 8 Kinases and its Types

Section 2: Signaling Pathways

Lecture 9 Fibroblast Growth Factor and Its Receptor

Lecture 10 Nonreceptor Tyrosine Kinase Mediated Cell Signaling; The Src signaling Pathway

Lecture 11 Receptor serine/threonine kinase mediated Cell Signaling; TGF beta pathway Part1

Lecture 12 Receptor serine/threonine kinase mediated Cell Signaling; TGF beta pathway Part2

Lecture 13 Protein Kinase A Pathway; Part 1

Lecture 14 Protein Kinase A Pathway; Part 2

Lecture 15 Protein Kinase A Pathway; Part 3

Lecture 16 Protein Kinase A Pathway; Part 4

Lecture 17 Protein Kinase A Pathway; Part 5

Lecture 18 Protein Kinase C; Part 1

Lecture 19 Protein Kinase C; Part 2

Section 3: Karyopherin

Lecture 20 Importins; movement of the proteins from the cytoplasm into the nucleus

Lecture 21 Exportins; movement of proteins from nucleus to cytoplasm

Section 4: Neuronal Signaling

Lecture 22 Structure of Neurons

Lecture 23 Types of Neurons

Lecture 24 Action Potential; how message travel along the axons

Lecture 25 Release of Neurotransmitters at the Synaptic Cleft

Section 5: Cell Cycle/ Cell Division and its importance to a good health

Lecture 26 Cell Cycle, Part 1: An introduction

Lecture 27 Cell Cycle: Part 2: Machinery of the Cell Cycle

Lecture 28 Cell Cycle; Part 3: Cell Cycle Control System

Lecture 29 Cell Cycle: Part 4: Events in the G1 phase of the cell cycle

Lecture 30 Cell Cycle: Part 5: Function of P53 when DNA is damaged

Lecture 31 Cell Cycle: Part 6: Function of G1-S CDK and S-CDK

Lecture 32 Cell Cycle: Part 7: Events in the S and G2 phase of cell cycle

Lecture 33 Cell Cycle: Part 8: G2 as a preparatory phase for M phase of cell cycle

Lecture 34 Cell Cycle: Part 9: Functions of M-CDK (CDK 1 + Cyclin B)

Lecture 35 Cell Cycle: Part 10: Events in the Metaphase

Lecture 36 Cell Cycle: Part 11: Role of Spindle Assembly Checkpoint

Lecture 37 Cell Cycle: Part 12: Function of Anaphase Promoting Complex and Contractile ring

Lecture 38 Cell Cycle: Part 13: Ubiquitin Proteasome Complex

For Undergraduate and Post graduate students