"The Cell Cycle: Principles of Control" by David O. Morgan

The modular structure of the text, and the transparency of its organization, make it easy for instructors to choose their own path through the material and for students to revise; or for working scientists using the book as an up-to-date reference to find the topics they want, and as much of the conceptual context of any individual topic as they may need.

The Cell Cycle is an account of the mechanisms that control cell division, beginning with a description of the phases and main events of the cell cycle and the main model organisms in cell-cycle analysis, including Xenopus, Drosophila, and yeasts. Later chapters focus on the molecules and mechanisms of the cell-cycle control system, including the cyclin-dependent kinase family of protein kinases, the cyclins that activate them, and the signaling molecules that regulate them, and discuss cell-cycle control in development and the failure of controls in cancer.

Contents summary
CHAPTER 1 The Cell Cycle
1-0 Overview: Cell Reproduction
1-1 Events of the Eukaryotic Cell Cycle
1-2 Variations in Cell-Cycle Organization
1-3 The Cell-Cycle Control System
CHAPTER 2 Model Organisms in Cell-Cycle Analysis
2-0 Overview: Cell-Cycle Analysis in Diverse Eukaryotes
2-1 Life Cycles of Budding and Fission Yeasts
2-2 Genetic Analysis of Cell-Cycle Control in Yeast
2-3 The Early Embryo of Xenopus laevis
2-4 The Fruit Fly Drosophila melanogaster
2-5 Mammalian Cell-Cycle Analysis
2-6 Methods in Cell-Cycle Analysis
CHAPTER 3 The Cell-Cycle Control System
3-0 Overview: The Cell-Cycle Control System
3-1 Cyclin-Dependent Kinases
3-2 Cyclins
3-3 Control of Cdk Activity by Phosphorylation
3-4 The Structural Basis of Cdk Activation
3-5 Substrate Targeting by Cyclin-Cdk Complexes
3-6 Cdk Regulation by Inhibitory Subunits
3-7 Biochemical Switches in Signaling Systems
3-8 Switch-Like Activation of Cdk1
3-9 Protein Degradation in Cell-Cycle Control
3-10 The Anaphase-Promoting Complex
3-11 Assembling and Regulating a Cell-Cycle Oscillator
3-12 Transcriptional Control of Cell-Cycle Regulators
3-13 Programming the Cell-Cycle Control System
CHAPTER 4 Chromosome Duplication
4-0 Overview: Chromosome Duplication and its Control
4-1 Basic Mechanisms of DNA Synthesis
4-2 The Replication Origin
4-3 Assembly of the Prereplicative Complex at the Replication Origin
4-4 Regulation of the Prereplicative Complex
4-5 Cyclins Required for Activation of Replication Origins in Yeast
4-6 Cyclins Required for Activation of Replication Origins in Metazoans
4-7 Control of Replication by the Protein Kinase Cdc7-Dbf4
4-8 Activation of the Replication Origin
4-9 Basic Chromatin Structure
4-10 Histone Synthesis in S phase
4-11 Nucleosome Assembly on Nascent DNA
4-12 Heterochromatin at Telomeres and Centromeres
4-13 Molecular Mechanisms of Heterochromatin Duplication
CHAPTER 5 Early Mitosis: Preparing the Chromosomes for Segregation
5-0 Overview: The Events of Mitosis
5-1 Overview: Principles of Mitotic Regulation
5-2 Cyclins that Promote Mitotic Entry in Yeast
5-3 Cyclins that Promote Mitotic Entry in Metazoans
5-4 Regulation of Mitotic Cdks by Wee1 and Cdc25
5-5 Switch-like Activation of Cyclin B-Cdkl at Mitosis
5-6 Subcellular Localization of Mitotic Regulators
5-7 Protein Kinases of the Polo and Aurora Families
5-8 Preparations for Mitosis: Sister-Chromatid Cohesion
5-9 Entry into Mitosis: Sister-Chromatid Condensation and Resolution
5-10 Regulation of Chromosome Condensation and Resolution
CHAPTER 6 Assembly of the Mitotic Spindle
6-0 Overview: The Mitotic Spindle
6-1 Microtubule Structure and Behavior
6-2 Microtubule Nucleation, Stability and Motility
6-3 The Centrosome and the Spindle Pole Body
6-4 Control of Centrosome Duplication
6-5 The Kinetochore
6-6 Early Steps in Spindle Assembly
6-7 Nuclear Envelope Breakdown
6-8 Mitotic Chromosome Function in Spindle Assembly
6-9 Attachment of Sister Chromatids to the Spindle
6-10 Bi-Orientation of Sister Chromatids
6-11 Forces Driving Chromosome Movement
6-12 Chromosome Congression
CHAPTER 7 The Completion of Mitosis
7-0 Overview: The Completion of Mitosis
7-1 Initiation of Anaphase: Activation of the APC
7-2 Initiation of Anaphase: The Spindle Checkpoint
7-3 Inhibition of APCcdc20 by the Spindle Checkpoint
7-4 Control of Sister-Chromatid Separation
7-5 Control of Late Mitosis in Budding Yeast
7-6 Control of Anaphase Events
7-7 Control of Telophase
CHAPTER 8 Cytokinesis
8-0 Overview: Cytokinesis
8-1 The Actin-Myosin Ring
8-2 Assembly and Contraction of the Actin-Myosin Ring
8-3 Membrane and Cell Wall Deposition at the Division Site
8-4 The Positioning and Timing of Cytokinesis in Yeast
8-5 The Positioning and Timing of Cytokinesis in Animal Cells
8-6 Specialization of Cytokinesis in Animal Development
8-7 Asymmetric Cell Division
CHAPTER 9 Meiosis
9-0 Overview: Meiosis
9-1 Regulation of Early Meiotic Events in Yeast
9-2 Homologous Recombination in Meiosis
9-3 Homolog Pairing in Meiotic Prophase
9-4 Chiasma Formation in Late Meiotic Prophase
9-5 Controlling Entry into the First Meiotic Division
9-6 Chromosome Attachment in Meiosis I
9-7 Chromosome Segregation in Meiosis I
9-8 Finishing Meiosis
CHAPTER 10 Control of Cell Proliferation and Growth
10-0 Overview: Control of Cell Proliferation and Growth
10-1 Activation of Gene Expression at Start in Budding Yeast 1
10-2 Activation of S-Cdks in Budding Yeast
10-3 Extracellular Control of Start in Yeast: Mating Factor Signaling 2
10-4 Activation of Gene Expression at Start in Animals
10-5 Regulation of E2F-pRB Complexes
10-6 Mitogenic Signaling in Animal Cells 2
10-7 Activation of G1-Cdks by Mitogens 2
10-8 Activation of G1/S- and S-Cdk Complexes in Animal Cells
10-9 Developmental Control of Cell Proliferation
10-10 Overview: Coordination of Cell Division and Cell Growth
10-11 Control of Cell Growth 2
10-12 Coordination of Cell Growth and Division in Yeast 2
10-13 Coordination of Growth and Division in Animal Cells
10-14 Control of Cell Death
CHAPTER 11 The DNA Damage Response
11-0 Overview: The DNA Damage Response
11-1 Detection and Repair of DNA Damage
11-2 The DNA Damage Response: Recruitment of ATR and ATM
11-3 The DNA Damage Response: Adaptors and Chkl and Chk2
11-4 Activation of p53 by DNA Damage
11-5 Effects of DNA Damage on Progression through Start
11-6 Effects of DNA Damage at Replication Forks
11-7 Effects of DNA Damage on DNA Synthesis and Mitosis
11-8 Responses to Mitogenic and Telomere Stress
CHAPTER 12 The Cell Cycle in Cancer
12-0 Overview: Cell-Cycle Defects in Cancer
12-1 Gene Mutations that Drive Cancer
12-2 Tissue Specificity in Cancer
12-3 Stimulation of Cell-Cycle Entry in Cancer Cells
12-4 Cell Growth and Survival in Tumors
12-5 Genetic Instability in Cancer
12-6 Telomeres and the Structural Instability of Chromosomes
12-7 Instability in Chromosome Number
12-8 Cancer Progression
12-9 Stopping Cancer
Glossary
References
Index