"Aldosterone-Mineralocorticoid Receptor: Cell Biology to Translational Medicine" ed. by Brian Harvey, Frederic Jaisser

This volume is dedicated to the physiology and pathophysiology. The book assembles chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system.

Contents
1.Mineralocorticoid Receptor Antagonists in the Treatment of Coronary Artery Disease, Myocardial Infarction and Heart Failure
2.Mineralocorticoid Receptor and Leptin: A Dangerous Liaison in the Obese Heart
3.Aldosterone/Mineralocorticoid Receptor Downstream Targets as Novel Therapeutic Targets to Prevent Cardiovascular Remodeling
4.Aldosterone/MR Signaling, Oxidative Stress, and Vascular Dysfunction
5.Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone
6.Primary Aldosteronism: A Glimpse into the Most Common Endocrine Cause of Arterial Hypertension
7.Potential Benefit of Mineralocorticoid Receptor Antagonists in Kidney Diseases
8.Mineralocorticoid Receptor in Novel Target Tissues: A Closer Look at the Adipocyte
9.Investigating the Role of Mineralocorticoid Receptor Signaling in Cancer Biology in the Genomic Era
10.MR/GR Signaling in the Brain during the Stress Response
11.View on Aldosterone and the Brain Revisited
12.Transcriptional Regulation and Epigenetics in Cardiovascular Cells: Role of the Mineralocorticoid Receptor
13.MicroRNAs in Aldosterone Production and Action
14.Post-Translational Modification of MR Activity
15.Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na+ Transport by Non-genomic Mechanisms
16.Advances in the Development of Non-steroidal Mineralocorticoid-receptor Antagonists
17.COLT: A New Weapon to Disseminate Knowledge