"Advanced Understanding of Neurodegenerative Diseases" ed. by Raymond Chuen-Chung Chang

This book focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions.

This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.

Contents
Part 1: Alzheimer's Disease a Dementia
1 Alzheimer's Disease: Definition, Molecular and Genetic Factors
2 Evidence for an Infectious Etiology in Alzheimer's Disease
3 Amyloid Hypothesis and Alzheimer's Disease
4 Structure-Toxicity Relationships of Amyloid Peptide Oligomers
5 Disruption of Calcium Homeostasis in Alzheimer's Disease: Role of Channel Formation by p Amyloid Protein
6 Recent Developments in Molecular Changes Leading to Alzheimer's Disease and Novel Therapeutic Approaches
7 Clinical Profile of Alzheimer's Disease Non-Responder Patient
8 Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase
9 Therapeutics of Alzheimer's Disease
10 Frontotemporal Lobar Degeneration
11 From Protein Tangles to Genetic Variants: The Central Role of Tau in Neurodegenerative Disease
Part 2: Parkinson's Disease
12 Gut Hormones Restrict Neurodegeneration in Parkinson's Disease
13 Grape Secondary Metabolites - Benefits for Human Health
Part 3: Prion Diseases
14 Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins
15 The Effects of Trimethylamine N-Oxide on the Structural Stability of Prion Protein
Part 4: Motor Neuron Diseases
16 Modeling Spinal Muscular Atrophy in Mouse: A Disease of Splicing, Stability, and Timing
17 Wallerian Degeneration in Injury and Diseases: Concepts and Prevention
18 Mesenchymal Stem Cell Therapy for Apoptosis After Spinal Cord Injury
19 Modelling Multiple Sclerosis in vitro and the Influence of Activated Macrophages
20 Amyotrophic Lateral Sclerosis