Acid Peptic Diseases and related disorders Pocket Guide: Full Illustrated

Acid peptic diseases are a large group of gastrointestinal disorders that is mainly characterized by excessive gastric acid secretion and diminished gastrointestinal defense. The most common acid peptic diseases encountered by gastroenterologists are gastroesophageal reflux disease and peptic ulcer disease. The two major causes of peptic ulcer disease are long-term use of non-steroidal anti-inflammatory drugs and infection with the bacterium Helicobacter pylori. Zollinger-Ellison syndrome is another acid peptic disease in which the development of a neuroendocrine pancreatic or duodenal tumor results in hypersecretion of gastric acid. Although all of these diseases have overlapping symptoms and pathogenic factors, clinical presentation and outcomes can vary considerably.
In recent decades, our understanding of the etiologies underlying acid peptic diseases has evolved, as have diagnosis and management strategies. In particular, proton pumps inhibitors have dramatically changed how acid peptic diseases are treated. They have emerged as the most potent drug class that suppress gastric acid secretion, prevent gastrointestinal complications and promote healing if they occur, without tachyphylaxis.
In this work, the pathogenesis underlying specific acid peptic diseases and related complications or disorders are described, and our current knowledge of the environmental, pathophysiological, and genetic factors that may contribute to disease etiologies is summarized. Importantly, key points and recommendations from internationally recognized diagnosis and management guidelines for these acid peptic diseases are stated. New advances in disease management are also discussed.

Table of Contents
Foreword
Abbreviations and Acronyms
Chapter 1: Gastroesophageal Reflux Disease and Its Complications
Overview
GERD pathogenesis
Lifestyle and environmental factors
Pathophysiology
Reflux esophagitis
Genetic and epigenetics of GERD
Genetic factors
Epigenetic factors
Epidemiology
Symptoms
Diagnosis
Management
Pharmacotherapy
PPIs
Lifestyle and diet modifications
Surgery and endoscopic surgery
Follow-up
Prognosis
Special concerns
Pediatric GERD
Epidemiology
Symptoms
Diagnosis
Management
Lifestyle modifications
Pharmacotherapy
Surgery
Follow-up
Prognosis for pediatric GERD patients
Special concerns for pediatric GERD patients
Complications associated with GERD
Dyspepsia
Symptoms
Diagnosis
Management
Prognosis
Erosive esophagitis
Epidemiology
Symptoms
Diagnosis
Management
Follow-up
Prognosis
Peptic strictures
Epidemiology
Symptoms
Diagnosis
Management
Dilation
Pharmacotherapy
Surgery
Prognosis
Barrett’s esophagus
Epidemiology
Symptoms
Diagnosis
Management
Surgery
Endoscopic therapy
Surveillance
Prognosis
Esophageal adenocarcinoma
New advances in the management of GERD
Conclusion
Chapter 2: Hiatal Hernia
Overview
Pathogenesis of sliding hiatal hernia
Anatomical features
Pathophysiology
Genetics
Other factors
Epidemiology
Symptoms
Diagnosis
Management
Lifestyle modifications
Pharmacotherapy
Surgery
Prognosis
Special concerns
New advances in the management of hiatal hernia
Conclusion
Chapter 3: Gastrointestinal Complications Related to Chronic NSAID Use
Overview
NSAIDs: mechanism of action
Pathogenesis
Pathophysiology
NSAIDs and small intestine injury
Risk factors
Genetics
Epidemiology
Symptoms
Diagnosis
Management
Prevention strategies
PPIs
Misoprostol
H2RAs
COX-2 inhibitors
PUD
Epidemiology
Symptoms
Diagnosis
Management
Pharmacotherapy for NSAID-induced PUD
PPIs
H2RAs
Surgery
Prognosis
Special concerns
Gastrointestinal bleeding or hemorrhage
Epidemiology
Symptoms
Diagnosis
Management
Endoscopic therapy
Pharmacotherapy
Antibiotics
PPIs
Follow-up
Prognosis
Special concerns
Conclusion
Chapter 4: Helicobacter Pylori Infection
Overview
H. pylori pathogenesis
Transmission
H. pylori colonization and location
Bacterial factors