Comparative Pharmacokinetics: Principles, Techniques, and Applications, Second Edition

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine.  New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.Content: Chapter 1 Introduction (pages 3–11): Chapter 2 Principles of Drug Movement in the Body (pages 13–25): Chapter 3 Quantitative Structure–Permeability Relationships (pages 27–38): Xin?Rui XiaChapter 4 Absorption (pages 39–71): Chapter 5 Distribution (pages 73–90): Jennifer BuurChapter 6 Renal Elimination (pages 91–111): Chapter 7 Hepatic Biotransformation and Biliary Excretion (pages 113–141): Ronald BaynesChapter 8 Compartmental Models (pages 143–186): Chapter 9 Noncompartmental Models (pages 187–206): Chapter 10 Nonlinear Models (pages 207–223): Chapter 11 Physiological Models (pages 225–240): Teresa LeavensChapter 12 Dosage Regimens (pages 241–254): Chapter 13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (pages 255–294): Pierre?Louis ToutainChapter 14 Study Design and Data Analysis (pages 295–313): Jason ChittendenChapter 15 Bioequivalence Studies (pages 315–346): Marilyn MartinezChapter 16 Population Pharmacokinetic Models (pages 347–378): Jason ChittendenChapter 17 Dosage Adjustments in Disease States (pages 379–397): Jennifer DavisChapter 18 Interspecies Extrapolations (pages 399–412): Chapter 19 Tissue Residues and Withdrawal Times (pages 413–424):