Inhibitors in Patients with Haemophilia

Edited by an orthopaedic surgeon and a haematologist who are leading specialists in the treatment of haemophilia, Inhibitors in Patients with Haemophilia reviews the different haemostatic products and protocols for the control of bleeding and surgery in haemophilic patients with inhibitors.The book draws together in a single volume all of the clinical issues involved in the treatment of inhibitors from numerous specialists worldwide. It will be an invaluable resource for all those treating inhibitors in people with haemophilia.Content: Chapter 1 Natural History of Inhibitors in Severe Haemophilia A and B: Incidence and Prevalence (pages 3–8): J.M. LusherChapter 2 Characterization of Inhibitors in Congenital Haemophilia (pages 9–13): K. Peerlinck and M. JacqueminChapter 3 Incidence and Prevalence of Inhibitors and Type of Blood Product in Haemophilia A (pages 14–20): T.T. Yee and C.A. LeeChapter 4 Genetic Basis of Inhibitor Development in Severe Haemophilia A and B (pages 21–26): J. Oldenburg and E. TuddenhamChapter 5 Methods: Plasmapheresis and Protein A Immunoadsorption (pages 29–35): E. BerntorpChapter 6 Venous Access in Children with Inhibitors (pages 36–41): R.C.R. LjungChapter 7 Immune Tolerance: High?Dose Regimen (pages 45–48): H.H. Brackmann and T. WallnyChapter 8 Immune Tolerance: Low?Dose Regimen (pages 48–54): E.P. Mauser?BunschotenChapter 9 Immune Tolerance and Choice of Concentrates (pages 55–58): W. KreuzChapter 10 Immune Tolerance: The North American Immune Tolerance Registry (pages 59–65): D.M. DiMichele and B.L. KronerChapter 11 The Treatment of Bleeding Episodes in Children (pages 69–73): J.M. TusellChapter 12 General Medical Management of Bleeding Episodes: Haemarthroses, Muscle Haematomas, Mucocutaneous Bleeding and Haematuria (pages 74–77): M. Quintana?Molina, V. Jimenez?Yuste, A. Villar?Camacho and F. Hernandez?NavarroChapter 13 Life? and Limb?Threatening Episodes and Intracranial Bleeds (pages 78–83): S. Schulman, E. Santagostino, R. Grossman and J.M. LusherChapter 14 Factor IX Inhibitors and Anaphylaxis (pages 87–91): I. WarrierChapter 15 Inhibitors in Mild and Moderate Haemophilia A (pages 92–97): C.R.M. Hay and C.A. LeeChapter 16 Acquired Inhibitors to Factor VIII (pages 98–112): C.M. Kessler and L. NemesChapter 17 Pathogenesis of Musculoskeletal Complications of Haemophilia (pages 115–119): E.C. Rodriguez?MerchanChapter 18 Orthopaedic Management of Haemarthroses (pages 120–125): E.C. Rodriguez?MerchanChapter 19 Chemical Synoviorthesis (pages 126–128): H.A. Caviglia, F. Fernandez?Palazzi, C. Pascual?Garrido, N. Moretti and R. Perez?BiancoChapter 20 Radiosynoviorthesis in Patients with Haemophilia and Inhibitors (pages 129–131): C.J. Petersson and E. BerntorpChapter 21 Musculoskeletal Magnetic Resonance Imaging (pages 132–138): R. Nuss, R.F. Kilcoyne and J.D. WiedelChapter 22 Treatment of Iliopsoas Haematomas and Compartment Syndromes in Patients with Haemophilia who Have a Circulating Antibody (pages 139–141): M. Heim, M. Warshavski, Y. Amit and U. MartinowitzChapter 23 A Rational Approach to the Treatment of Haemophilic Blood Cyst (Pseudotumour) in Patients with Inhibitors (pages 142–145): M.S. Gilbert and A. ForsterChapter 24 Haemophilia Patients with Inhibitors: A Rheumatologist's Point of View (pages 146–148): J. YorkChapter 25 Rehabilitation of Patients with Haemophilia and Inhibitors (pages 149–159): F. Querol, J.A. Aznar, S. Haya and A.R. CidChapter 26 Physiotherapy in the Management of Patients with Inhibitors (pages 160–168): K. Beeton and B. BuzzardChapter 27 Elective Orthopaedic Surgery in Haemophilia Patients with Highresponding Inhibitors (pages 169–176): I. Hvid, K. Soballe and J. IngerslevChapter 28 General and Emergency Surgery in Patients with High?Responding Inhibitors (pages 179–182): B. White and O.P. SmithChapter 29 Dental Extraction in Patients with Haemophilia and Inhibitors (pages 183–184): E.A. Rey, S.A. Puia and W. CastilloChapter 30 Psychosocial Impact of Inhibitors on Haemophilia Patients' Quality of Life (pages 187–192): E. Remor, P. Arranz and R. MillerChapter 31 General Strategy for Management of Inhibitor Patients (Summary) (pages 195–198): I. ScharrerChapter 32 Immunoadsorption with Antiimmunoglobulin Antibodies Using Ig?TheraSorb Columns (pages 199–205): M. von Depka and A. Huth?KuehneChapter 33 Standard, High and Mega Bolus Doses of rVIIa or Recombinant VIIa: Comparison of Three Different Treatment Regimens (pages 206–210): G. Kenet and U. Martinowitz