Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions (Repost)
Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions By Elisabetta Brenna
2013 | 408 Pages | ISBN: 3527333878 | PDF | 7 MB
2013 | 408 Pages | ISBN: 3527333878 | PDF | 7 MB
This useful reference focuses on the currently available toolbox of bio–catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2–4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole–cell catalysts and isolated enzymes. Chapters 5–7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8–12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio–reductions for the synthesis of active pharmaceutical ingredients. With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry.