Glycosciences: Status and Perspectives

A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes. Content: Chapter 1 The Information?Storing Potential of the Sugar Code (pages 1–14): Roger A. LaineChapter 2 Methods of Glycoconjugate Analysis (pages 15–29): Elizabeth F. HounsellChapter 3 Strategies for the Chemical Synthesis of Glycoconjugates (pages 31–53): Richard R. SchmidtChapter 4 Neoglycoconjugates (pages 55–77): Reiko T. Lee and Yuan C. LeeChapter 5 Glycosyltransferases Involved in N–and O–Glycan Biosynthesis (pages 79–113): Inka Brockhausen and Harry SchachterChapter 6 Topology of Glycosylation — a Histochemist's View (pages 115–120): Margit PavelkaChapter 7 Occurrence and Potential Functions of N–Glycanases (pages 121–131): Tadashi Suzuki, Ken Kitajima, Sadako Inoue and Yasuo InoueChapter 8 Glycoproteins: Structure and Function (pages 133–162): Nathan Sharon and Halina LisChapter 9 Glycolipids: Structure and Function (pages 163–189): Jorgen KopitzChapter 10 Lectins as Tools for Glycoconjugate Purification and Characterization (pages 191–199): Richard D. CummingsChapter 11 Proteoglycans – Structure and Functions (pages 201–222): Hans KresseChapter 12 GPI–Anchors: Structure and Functions (pages 223–243): Volker Eckert, Peter Gerold and Ralph Thomas SchwarzChapter 13 The Biology of Sialic Acids: Insights into their Structure, Metabolism and Function in Particular during Viral Infection (pages 245–259): Werner Reutter, Roger Stasche, Peer Stehling and Oliver BaumChapter 14 The Biology of Sulfated Oligosaccharides (pages 261–276): Lora V. Hooper, Stephen M. Manzella and Jacques U. BaenzigerChapter 15 Carbohydrate–Carbohydrate Interaction (pages 277–289): Nlcolai V. BovinChapter 16 Carbohydrate–Protein Interaction (pages 291–310): Hans?Christian Siebert, Claus?Wilhelm Von Der Lieth, Martine Gilleron, Gerd Reuter, Josef Wittmann, Johannes F. G. Vliegenthart and Hans?Joachim GabiusChapter 17 Antibody–Oligosaccharide Interactions Determined by Crystallography (pages 311–331): David R. BundleChapter 18 Thermodynamic Analysis of Protein–Carbohydrate Interaction (pages 333–343): Dipti Gupta and C. F. BrewerChapter 19 Analysis of Protein–Carbohydrate Interaction Using Engineered Ligands (pages 345–354): Dolores Solis and Teresa Diaz?MaurinoChapter 20 Application of Site–Directed Mutagenesis to Structure–Function Studies of Carbohydrate–Binding Proteins (pages 355–368): Jun HirabayashiChapter 21 Bacterial Lectins: Properties, Structure, Effects, Function and Applications (pages 369–396): N. Gilboa?Garber, D. Avichezer and N. C. GarberChapter 22 Glycobiology of Parasites: Role of Carbohydrate–Binding Proteins and Their Ligands in the Host–Parasite Interaction (pages 399–413): Honorine D. WardChapter 23 Structure and Function of Plant Lectins (pages 415–438): Harold RudigerChapter 24 Lectins and Carbohydrates in Animal Cell Adhesion and Control of Proliferation (pages 439–458): Jean?Pierre ZanettaChapter 25 Galectins in Tumor Cells (pages 459–469): David W. Ohannesian and Reuben LotanChapter 26 Glycoconjugate–Mediated Drug Targeting (pages 471–483): Kevin G. RiceChapter 27 Glycobiology of Signal Transduction (pages 485–496): Antonio Villalobo, Jose Antonio Horcajadas, Sabine Andre and Hans?J. GabiusChapter 28 Glycobiology of Host Defense Mechanisms (pages 497–505): Hans?J. Gabius, Klaus Kayser, Sabine Andre and Sigrun GabiusChapter 29 Transgenic Approaches to Glycobiology (pages 507–517): Helen J. Hathaway and Barry D. ShurChapter 30 Biomodulation, the Development of a Process–Oriented Approach to Cancer Treatment (pages 519–529): Paul L. Mann, Rebecca Wenk and Mary A. Raymond?StintzChapter 31 Glycobiology in Xenotransplantation Research (pages 531–545): David K. C. Cooper and Raffael OriolChapter 32 Modern Glycohistochemistry: A Major Contribution to Morphological Investigations (pages 547–562): Andre Danguy, Isabelle Camby, Isabelle Salmon and Robert KissChapter 33 Lectins and Neoglycoproteins in Histopathology (pages 563–583): S. Kannan and M. Krishnan NairChapter 34 Glycobiology of Development: Spinal Dysmorphogenesis in Rat Embryos Cultured in a Hyperglycemic Environment (pages 585–594): Lori Keszler?Moll, Amy Garcia, Marisa Braun, Mary A. Raymond?Stintz, Paul L. Mann, Jim Hanosh and Robert O. KelleyChapter 35 Glycobiology of Fertilization (pages 595–610): Fred Sinowatz, Edda Topfer?Petersen and Juan J. CalveteChapter 36 Glycobiology of Consciousness (pages 611–617): Raymonde Joubert?Caron, Didier Lutomski, Dominique Bladier and Michel Caron