Toxikologie: Eine Einfuhrung fur Naturwissenschaftler und Mediziner

Nowadays as a result of an increased awareness of their social and ecological responsibilities more and more scientists and physicians wish to increase their current knowledge of poisons and the effects of these on human beings and the environment. This is increasingly true of chemists and biologists, who have already been confronted, during their studies, with questions concerning the health risks of chemicals and the legal regulations involved. This book is a modern introduction to toxicology and treats these topics. Starting from the medical, biochemical and pharmacological fundamentals it describes the methods used for recognizing and assessing toxicological risks. There is a detailed treatment of mechanisms and detection methods for genotoxic, reproduction-toxic and carcinogenic chemicals in the laboratory, at the place of work and in the environment. All the authors are eminent: years of experience at the forefront of academic and industrial research and teaching have brought them not only technical but also outstanding didactic competence. Their contributions are clearly structured in 35 chapters and form a richly illustrated presentation. Content: Chapter 1 Einfuhrung (pages 1–12): Prof. Dr. H. GreimChapter 2 Toxikokinetik (pages 13–40): J. G. FilserChapter 3 Fremdstoffmetabolismus (pages 41–85): Th. Wolff and L. R. SchwarzChapter 4 Reaktive Metaboliten und kovalente Bindung an Makromolekule (pages 87–105): H. KappusChapter 5 Toxikogenetik (pages 107–116): F. J. WiebelChapter 6 Cytotoxizitat (pages 117–134): L. R. SchwarzChapter 7 Chemische Kanzerogenese (pages 135–160): E. Deml and D. OesterleChapter 8 Reproduktionstoxikologie (pages 161–170): H. SpielmannChapter 9 Kombinationswirkungen von Chemikalien (pages 171–177): H. M. Bolt and F. RiemerChapter 10 Verdauungstrakt (pages 179–187): M. SchwenkChapter 11 Leber (pages 189–198): L. R. SchwarzChapter 12 Atmungsorgane (pages 199–212): J. PauluhnChapter 13 Herz (pages 213–220): K. SeibelChapter 14 Zentralnervensystem (ZNS) und peripheres Nervensystem (pages 221–232): W. E. MullerChapter 15 Haut (pages 233–241): F. J. WiebelChapter 16 Niere und ableitende Harnwege (pages 243–253): D. OesterleChapter 17 Knochenmark, zellulare Bestandteile des Blutes und Hamoglobin (pages 255–268): W. Lenk, R. Snyder and Prof. Dr. H. GreimChapter 18 Immunsystem (pages 269–302): P. Greim, C. Goebel, J. Abel, H. Schroder and E. GleichmannChapter 19 Toxizitatstests und Kanzerogenitatstests in vivo (pages 303–320): Dr. E. DemlChapter 20 Genotoxizitatstests in vitro (pages 321–341): U. AndraeChapter 21 Mutagenitatstests in vivo (pages 343–356): I?D. AdlerChapter 22 Erfassung und Kontrolle von Schadstoffbelastungen beim Individuum (Biomonitoring) (pages 357–370): Th. WolffChapter 23 Epidemiologie (pages 371–380): K. UlmChapter 24 Risikoabschatzungen fur krebserzeugende Stoffe (pages 381–396): J. Filser, Prof. Dr. H. Greim and J. TimmChapter 25 Grenzwerte (pages 397–409): Prof. Dr. H. GreimChapter 26 Gesetzgeberische Aspekte (pages 411–418): D. KayserChapter 27 Rechtsvorschriften zum Schutz vor gefahrlichen Stoffen (pages 419–440): E. Hummel and W. MuckeChapter 28 Polychlorierte Biphenyle (pages 441–450): Dr. E. DemlChapter 29 Polychlorierte Dibenzodioxine und Dibenzofurane (PCDD/F) (pages 451–461): K. Rozman, B. Stahl and H. Sterzl?EckertChapter 30 Metalle (pages 463–478): K. H. Summer and St. HalbachChapter 31 Toxische Gase (pages 479–491): L. SziniczChapter 32 Stickstoffmonoxid (pages 493–498): J. Stadler and J. DoehmerChapter 33 Mineralfasern (pages 499–506): I. MangelsdorfChapter 34 Organische Losungsmittel (pages 507–517): Prof. Dr. H. GreimChapter 35 Okotoxikologie (pages 519–539): R. Debus