Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.Content: Chapter 1 Neuronal L?Type Voltage?Gated Calcium Channels (pages 1–34): Alexander Scriabine and David J. TriggleChapter 2 Voltage?Gated N?Type and T?Type Calcium Channels and Excitability Disorders (pages 35–66): Elizabeth Tringham and Terrance P. SnutchChapter 3 Voltage?Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (pages 67–104): Sulayman D. Dib?Hajj, Bryan C. Hains, Joel A. Black and Stephen G. WaxmanChapter 4 The Role of Ion Channels in the Etiology and Development of Gliomas (pages 105–126): Amy K. Weaver and Harald SontheimerChapter 5 Shaker Family Kv1 Voltage?Gated Potassium Channels in Mammalian Brain Neurons (pages 127–154): Helene Vacher and James S. TrimmerChapter 6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (pages 155–191): Elizabeth A. JonasChapter 7 Regulation of Neuronal Excitability by the Sodium?Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (pages 193–215): Valentin K. Gribkoff and Leonard K. KaczmarekChapter 8 Alternative Splicing of Neuronal Cav2 Calcium Channels (pages 217–250): Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis and Jesica RaingoChapter 9 Effect of Hypoxia/Ischemia on Voltage?Dependent Channels (pages 251–277): Xiang Q. Gu, Hang Yao and Gabriel G. HaddadChapter 10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (pages 279–289): Smitha Reddy, Mohammad Shahidullah and Irwin B. LevitanChapter 11 Regulation of Neuronal Ion Channels by G?Protein?Coupled Receptors in Sympathetic Neurons (pages 291–316): Mark S. Shapiro and Nikita GamperChapter 12 BK Channels: Regulation of Expression and Physiological Impact (pages 317–342): Pallob Kundu, Abderrahmane Alioua, Yogesh Kumar, Rong Lu, Jimmy W. Ou, Enrique Sanchez?Pastor, Min Li, Enrico Stefani and Ligia ToroChapter 13 Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (pages 343–361): KeWei Wang and Jijie ChaiChapter 14 Sodium Channel Blockers for the Treatment of Chronic Pain (pages 363–391): Mark R. Bowlby and Edward KaftanChapter 15 Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (pages 393–421): Steven I. Dworetzky and Valentin K. GribkoffChapter 16 Small?Molecule Modulators of Large?Conductance, Calcium?Activated (BK) Channels (pages 423–441): John E. StarrettChapter 17 High?Throughput Screening Technologies in Ion Channel Drug Discovery (pages 443–466): Edward B. Stevens, Andrew D. Whyment and J. Mark Treherne