Transgenics in Endocrinology

Transgenic mouse technology, including embryonic stem cell and gene knockout techniques, has revolutionized the study of endocrinology by giving endocrinologists an effective set of tools for understanding endocrine physiology and pathology in vivo. In Transgenics in Endocrinology, a panel of expert clinical and basic investigators summarize the state-of-the-art in the use of this powerful technology in a broad range of endocrinological applications. These applications include studies of mammalian sexual differentiation, steroidogenesis, progesterone action in vivo, normal mammary gland development, oxytocin and vasopressin, regulation and function, skeletal biology, and prostate cancer. There are also transgenic studies of the control of ovarian function, the Bcl2 gene family, c-kit/kit ligand axis in mammalian gametogenesis, prolactin and the prolactin receptor, insulin and insulin-like growth factors, and overexpression and targeted disruption of genes involved in the control of growth, food intake, and obesity. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology, and its pathologies, through mouse models, and provides a host of creative approaches to better understand the complex processes characteristic of hormonal systems.