Cell Engineering: Apoptosis
Cell Engineering: Apoptosis by Martin Fussenegger
English | 13 July 2004 | ISBN: 1402022166 | 337 Pages | PDF | 4 MB
English | 13 July 2004 | ISBN: 1402022166 | 337 Pages | PDF | 4 MB
The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated.