Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition

THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientistsPreviously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people).Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors.It includes unique sections on:Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systemsIt’s bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more.Plus, it comes with a fully searchable CD ROM of the entire content.Click here to view a sample chapter on the liver and coagulationContent: Chapter 1.1 Macroscopic Anatomy of the Liver (pages 1–8): Jean H.D. Fasel, Holger Bourquain, Heinz?Otto Peitgen and Pietro E. MajnoChapter 1.2 Liver and Biliary Tract Histology (pages 9–19): Paulette Bioulac?Sage, Brigitte Le Bail and Charles BalabaudChapter 1.3 Ultrastructure of the Hepatocyte (pages 20–28): Zahida Khan, James M. Crawford and Donna B. StolzChapter 1.4 Liver Sinusoidal Endothelial Cells (pages 29–35): David Semela and Vijay H. ShahChapter 1.5 Kupffer Cells (pages 36–42): Hartmut JaeschkeChapter 1.6 The Hepatic Stellate Cell (pages 43–51): Massimo PinzaniChapter 1.7 Biliary Epithelial Cells (pages 52–57): Jean?Francois DufourChapter 1.8 Hepatic Stem Cells (pages 58–64): Tania RoskamsChapter 1.9 Embryology of the Liver and Intrahepatic Biliary Tract (pages 65–71): Frederic P. LemaigreChapter 2.1 Hepatic Circulation (pages 73–88): Christophe Bureau, Jean?Marie Peron, Jean?Pierre Vinel, Yoshiya Ito, Robert S. McCuskey, Glen A. Laine and Charles S. CoxChapter 2.2 Functions of the Liver (pages 89–128): Paulo Renato, A. V. Correa, Michael H. Nathanson, Allan W. Wolkoff, Phyllis M. Novikoff, Sundararajah Thevananther, Saul J. Karpen, Ronald P.J.Oude Elferink, Gerhard P. Puschel and Bruno StiegerChapter 2.3 Metabolism (pages 129–249): Guenther Boden, Erez F. Scapa, Keishi Kanno, David E. Cohen, Margaret E. Brosnan, John T. Brosnan, Dominique Pessayre, Namita Roy?Chowdhury, Yang Lu, Jayanta Roy?Chowdhury, Peter L.M. Jansen, Klaas Nico Faber, Dieter Haussinger, Vishwanath R. Lingappa, Jose C. Fernandez?Checa, Carmen Garcia?Ruiz, Herve Puy, Jean?Charles Deybach, Masataka Okuno, Rie Matsushima?Nishiwaki, Soichi Kojima, Kyle E. Brown, George J. Brewer, Edward D. Harris, Fred K. Askari, Brent A. Neuschwander?Tetri, Chris Liddle and Catherine A.M. StedmanChapter 2.4 Synthetic Function (pages 250–273): Richard A. Weisiger, Maria T. DeSancho, Stephen M. Pastores and Rebecca G. WellsChapter 2.5 Regulation of the Liver Cell Mass (pages 274–289): Nisar P. Malek, K. Lenhard Rudolph and Anna Mae DiehlChapter 2.6 Excretion (pages 290–311): Martin Wagner, Michael Trauner, Mayank Bhandari and James ToouliChapter 2.7 Immunology of the Liver (pages 312–331): Tom Luedde, Christian Trautwein, Wajahat Z. Mehal, Alvin B. Imaeda and Wajahat Z. MehalChapter 3.1 Hepatocyte Apoptosis and Necrosis (pages 333–347): Henning Schulze?Bergkamen, Marcus Schuchmann and Peter R. GalleChapter 3.2 Ischaemia?Reperfusion Injury to the Liver (pages 348–355): Nazia Selzner and Pierre A. ClavienChapter 3.3 Genetics and Liver Diseases (pages 356–383): Hongjin Huang, Ramsey Cheung, Peter T. Donaldson and Frank LammertChapter 3.4 Cellular Cholestasis (pages 384–390): Stefano FiorucciChapter 3.5 Oncogenes and Tumour Suppressor Genes (pages 391–397): Dipankar Chattopadhyay and Helen ReevesChapter 3.6 Genomics, Gene Arrays and Proteomics in the Study of Liver Disease (pages 398–420): Geoffrey W. McCaughan, Nicholas A. Shackel, Rohan Williams, Devanshi Seth, Paul S. Haber and Mark D. GorrellChapter 4.1 Histological Features (pages 421–432): Valeer J. Desmet, Tania Roskams and Miguel BrugueraChapter 4.2 Classifications, Scoring Systems and Morphometry in Liver Pathology (pages 433–440): Pierre Bedossa and Valerie ParadisChapter 5.1 Signs and Symptoms of Liver Disease (pages 441–450): Jurg ReichenChapter 5.2 Biochemical Investigations in the Management of Liver Disease (pages 451–467): Igino Rigato, J. Donald Ostrow and Claudio TiribelliChapter 5.3 Hepatic Removal Kinetics: Importance for Quantitative Measurements of Liver Function (pages 468–478): Susanne Keiding and Michael SorensenChapter 5.4 Immunological Investigations in Liver Diseases (pages 479–488): Elmar Jaeckel and Michael P. MannsChapter 5.5 Biopsy and Laparoscopy (pages 489–499): Arthur ZimmermannChapter 5.6 Imaging of the Liver (pages 500–548): Luigi Bolondi, Valeria Camaggi, Fabio Piscaglia, Daniel T. Cohen, Dushyant V. Sahani, Christoforos Stoupis, Sanjeeva P. Kalva, Dushyant V. Sahani, Alan J. Wigg and James ToouliChapter 5.7 Interventional Radiology in Hepatobiliary Diseases (pages 549–560): Jose Ignacio Bilbao Jaureguizar, Concepcio Bru, Joan Falco Fages and Lluis DonosoChapter 5.8 Positron Emission Tomography of the Liver (pages 561–566): Michael Sorensen and Susanne KeidingChapter 5.9 Splanchnic Haemodynamic Investigations (pages 567–571): Didier Lebrec and Richard MoreauChapter 5.10 The Cochrane Hepatobiliary Group (pages 572–579): Christian GluudChapter 6.1 The Evolution of Cirrhosis (pages 581–589): John P. Iredale and I. Neil GuhaChapter 6.2 Cellular and Molecular Pathobiology of Liver Fibrosis and its Pharmacological Intervention (pages 590–603): Scott L. FriedmanChapter 6.3 Clinical and Diagnostic Aspects of Cirrhosis (pages 604–619): I. Neil Guha and John P. IredaleChapter 7.1 Anatomy of the Portal Venous System in Portal Hypertension (pages 621–629): J. Michael HendersonChapter 7.2 Pathogenesis of Portal Hypertension (pages 630–639): Roberto J. Groszmann and Juan G. AbraldesChapter 7.3 Clinical Manifestations and Management of Bleeding Episodes in Cirrhotics (pages 640–657): Jaime Bosch, Juan G. Abraldes and Juan Carlos Garcia?PaganChapter 7.4 Haemodynamic Assessment of Portal Hypertension (pages 658–665): Juan Carlos Garcia?Pagan, Juan Turnes and Jaime BoschChapter 7.5 Pathogenesis, Diagnosis and Treatment of Ascites in Cirrhosis (pages 666–710): Vicente Arroyo, Carlos Terra and Luis Ruiz?del?ArbolChapter 7.6 Hepatorenal Syndrome (pages 711–719): Pere Gines and Monica GuevaraChapter 7.7 Pulmonary Complications of Portal Hypertension (pages 720–727): Michael J. KrowkaChapter 7.8 Hepatic Encephalopathy (pages 728–760): J. Michael HendersonChapter 7.9 Bacterial Infections in Portal Hypertension (pages 761–770): Javier Fernandez and Miguel NavasaChapter 7.10 Hypersplenism (pages 771–778): P. Aiden McCormickChapter 8.1 Congenital Conditions (pages 779–809): Jean?Pierre Benhamou, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Jean?Pierre Benhamou, Jean?Pierre Benhamou and Jean?Francois CadranelChapter 8.2 Acquired Conditions (pages 810–817): Jean?Francois CadranelChapter 9.1 Viral Hepatitis (pages 819–956): Mario Rizzetto and Fabien ZoulimChapter 9.2 Systemic Virosis Producing Hepatitis (pages 957–973): Alberto Biglino and Mario RizzettoChapter 9.3 Human Immunodeficiency Virus and the Liver (pages 974–987): Vincent Soriano, Pablo Barreiro, Javier Garcia?Samaniego, Luz Martin?Carbonero and Marina NunezChapter 9.4 Exotic Virus Infections of the Liver (pages 988–998): Pierre E. Rollin, Thomas G. Ksiazek, Alberto Queiroz Farias and Flair Jose CarrilhoChapter 10.1 Bacterial, Rickettsial and Spirochaetal Infections (pages 999–1010): Jose M. Sanchez?TapiasChapter 10.2 Fungal Infections Affecting the Liver (pages 1011–1019): Roderick J. HayChapter 10.3 Protozoal Infections Affecting the Liver (pages 1020–1039): David Kershenobich, Guillermo Robles Diaz, Juan Miguel Abdo, Montse Renom, Pedro L. Alonso and Manuel CorachanChapter 10.4 Helminthiasis (pages 1040–1067): Flair Carrilho, Pedro Paulo Chieffi, Luiz Caetano Da Silva, S. Bresson?Hadni, G.A. Mantion, J.P Miguet, D.A. Vuitton, Marcelo Simao Ferreira and Edna StraussChapter 11.1 Primary Biliary Cirrhosis (pages 1069–1088): E. Jenny Heathcote and Piotr MilkiewiczChapter 11.2 Autoimmune Hepatitis (pages 1089–1102): Diego Vergani and Giorgina Mieli?VerganiChapter 11.3 Sclerosing Cholangitis (pages 1103–1110): Konstantinos N. Lazaridis and Nicholas F. LaRussoChapter 11.4 Vanishing Bile Duct Syndrome (pages 1111–1119): Frank Grunhage and Tilman SauerbruchChapter 11.5 Overlap Syndromes (pages 1120–1126): Ulrich BeuersChapter 12.1 Epidemiological Aspects of Alcoholic Liver Disease (pages 1127–1134): Juan CaballeriaChapter 12.2 Ethanol Metabolism and Pathogenesis of Alcoholic Liver Injury (pages 1135–1147): Stephen F. Stewart and Chris P. DayChapter 12.3 Pathology of Alcoholic Liver Disease (pages 1148–1156): Elie Serge ZafraniChapter 12.4 Alcoholic Liver Disease: Natural History, Diagnosis, Clinical Features, Evaluation, Prognosis and Management (pages 1157–1178): Laurent Spahr and Antoine HadengueChapter 12.5 Management of the Alcoholic Patient, Including Alcoholism and Extrahepatic Manifestations (pages 1179–1191): Georges?Philippe Pageaux and Pascal PerneyChapter 13 Non?Alcoholic Fatty Liver and Non?Alcoholic Steatohepatitis (pages 1193–1208): Geoffrey C. FarrellChapter 14.1 Drug?Induced Liver Injury (pages 1209–1268): Dominique Pessayre and Dominique LarreyChapter 14.2 Toxic Liver Injury (pages 1269–1276): Basuki Gunawan and Neil KaplowitzChapter 14.3 Hepatic Injury Due to Physical Agents (pages 1277–1280): Bernhard H. Lauterburg and Haithem ChtiouiChapter 14.4 Hepatic Toxicity Induced by Herbal Medicines (pages 1281–1288): Felix Stickel and Detlef SchuppanChapter 15 Acute Liver Failure and Related Syndromes (pages 1289–1312): Francois Durand and Jacques BernuauChapter 16.1 Wilson's Disease (pages 1313–1322): Michael SchilskyChapter 16.2 Haemochromatosis (pages 1323–1329): Antonello PietrangeloChapter 16.3 Alpha?1?Antitrypsin Deficiency and Related Disorders (pages 1330–1335): Jeffrey H. TeckmanChapter 16.4 The Liver in Cystic Fibrosis (pages 1336–1342): Andrew P. FeranchakChapter 16.5 Human Hereditary Porphyrias (pages 1343–1351): Elisabeth Irene Minder and Xiaoye Schneider?YinChapter 16.6 Hyperbilirubinaemia (pages 1352–1359): Peter L.M. JansenChapter 16.7 The Liver in Intracellular and Extracellular Lipidosis (pages 1360–1369): Dominique P. GermainChapter 16.8 Glycogen Storage Diseases (pages 1370–1376): Philippe LabruneChapter 16.9 Mitochondriopathies (pages 1377–1382): Pierre RustinChapter 16.10 Genetic Cholestatic Diseases (pages 1383–1388): Ronald P.J. Oude ElferinkChapter 17.1 Hepatic Artery Diseases (pages 1389–1394): Peter C. HayesChapter 17.2 Obstruction of the Portal Vein (pages 1395–1402): Juan Carlos Garcia?Pagan, Manuel Hernandez?Guerra and Jaime BoschChapter 17.3 Disorders of the Hepatic Veins and Hepatic Sinusoids (pages 1403–1417): Dominique?Charles VallaChapter 17.4 Congenital Vascular Malformations (pages 1418–1423): Guadalupe Garcia?TsaoChapter 18.1 Benign Hepatic Tumours (pages 1425–1436): Jean?Pierre Benhamou, Massimo Colombo and Riccardo LencioniChapter 18.2 Malignant Tumours (pages 1437–1463): Jordi Bruix, Alejandro Forner, Maria Varela, Carmen Ayuso, Josep Maria Llovet, Miguel Bruguera and Juan RodesChapter 18.3 Metastatic Tumours (pages 1464–1478): Masamichi Kojiro, Antoni Castells and Humphrey J.F. HodgsonChapter 19.1 Intrahepatic Cholestasis (pages 1479–1500): Olivier Chazouilleres and Chantal HoussetChapter 19.2 Extrahepatic Biliary Obstruction: Systemic Effects, Diagnosis and Management (pages 1501–1517): Michelle C. Gallagher and James S. DooleyChapter 19.3 Gallstone Disease (pages 1518–1540): Frank Lammert, Franz?Ludwig Dumoulin and Tilman SauerbruchChapter 19.4 Cholangitis and Biliary Tract Infections (pages 1541–1549): Ulrich BeuersChapter 19.5 Haemobilia (pages 1550–1560): Antonio Lacy and Nader K. FrancisChapter 19.6 Biliary Dyskinesia (pages 1561–1572): C. Ritchie Chalmers and Giles J. ToogoodChapter 19.7 Benign Biliary Tumours (pages 1573–1574): Miguel BrugueraChapter 19.8 Gallbladder Carcinoma (pages 1575–1582): Thomas A. Aloia, Christopher H. Crane and Jean?Nicolas VautheyChapter 19.9 Cholangiocarcinoma (pages 1583–1605): Steven M. Strasberg and William G. HawkinsChapter 20.1 The Liver in Cardiovascular Disease (pages 1607–1615): Susan Tiukinhoy?Laing, Andres T. Blei and Mihai GheorghiadeChapter 20.2 The Liver in Lung Diseases (pages 1616–1621): Andres T. Blei and Jacob I. SznajderChapter 20.3 The Effect of Gastrointestinal Diseases on the Liver and Biliary Tract (pages 1622–1633): Roger W. Chapman and Peter W. AngusChapter 20.4 Total Parenteral Nutrition?Related Liver Disease (pages 1634–1641): Sean W.P. Koppe and Alan L. BuchmanChapter 20.5 The Effect of Skin Diseases on the Liver (pages 1642–1652): Daniel Glass and Malcolm RustinChapter 20.6 The Liver in Urogenital Diseases (pages 1653–1661): Monica Guevara, Vicente Arroyo and Juan RodesChapter 20.7 The Effect of Haematological and Lymphatic Diseases on the Liver (pages 1662–1670): Miguel Bruguera and Rosa MiquelChapter 20.8 The Liver in Graft?vs.?Host Disease (pages 1671–1679): Enric Carreras, Carmen Martinez and Miguel BrugueraChapter 20.9 The Effect of Endocrine Diseases on Liver Function (pages 1680–1693): Anthony J. DeSantis and Andres T. BleiChapter 20.10 Musculoskeletal Diseases and the Liver (pages 1694–1701): N. Guanabens, J. Van Den Bogaerde and H.L.C. BeynonChapter 20.11 Amyloidosis (pages 1702–1708): Philip N. HawkinsChapter 20.12 Hepatic Granulomas (pages 1709–1717): Laura M. Kulik and Andres T. BleiChapter 21.1 The Effect of Liver Disease on the Cardiovascular System (pages 1719–1731): Jens H. Henriksen and Soren MollerChapter 21.2 The Effect of Liver Disease on the Endocrine System (pages 1732–1766): Yolanta T. Kruszynska and Pierre M. BoulouxChapter 21.3 Haematological Abnormalities in Liver Disease (pages 1767–1779): Marco Senzolo and Andrew K. BurroughsChapter 21.4 Haemostasis in Liver Disease (pages 1780–1797): Stephen H. Caldwell, Patrick G. Northup and Vinay SundaramChapter 21.5 The Effect of Liver Disease on the Gastrointestinal Tract (pages 1798–1803): Roger W. Chapman and Peter W. AngusChapter 21.6 The Effect of Liver Disease on the Skin (pages 1804–1814): Malcolm Rustin and Daniel GlassChapter 21.7 The Effect of Liver Disease on the Urogenital Tract (pages 1815–1821): Monica Guevara, Vicente Arroyo and Juan RodesChapter 21.8 The Nervous System in Liver Disease (pages 1822–1828): Andres T. BleiChapter 21.9 The Effect of Liver Disease on Bone (pages 1829–1835): Juliet CompstonChapter 21.10 The Effect of Liver Disease on Nutritional Status and Energy Metabolism (pages 1836–1842): Michael R. CharltonChapter 22.1 Paediatric Liver Diseases (pages 1843–1869): Marianne Samyn and Giorgina Mieli?VerganiChapter 22.2 Liver Diseases in the Elderly (pages 1870–1878): Oliver F.W. JamesChapter 22.3 Liver Diseases and Pregnancy (pages 1879–1895): Andrew K. Burroughs and Evangelos CholongitasChapter 23.1 The General Management of Liver Diseases (pages 1897–1904): Dominique GuyaderChapter 23.2 Nutritional Aspects of Liver and Biliary Disease (pages 1905–1911): Bernard CampilloChapter 23.3 Prescribing Drugs in Liver Disease (pages 1912–1921): Dominique Larrey and Georges?Philippe PageauxChapter 23.4 Management of Pretransplant Patients (pages 1922–1930): Francois DurandChapter 24.1 General Surgical Aspects and the Risks of Liver Surgery in Patients with Hepatic Disease (pages 1931–1937): Jacques Belghiti and Satoshi OgataChapter 24.2 Anaesthesia and Liver Disease (pages 1938–1944): Kalpana Reddy and Susan V. MallettChapter 24.3 Postoperative Jaundice (pages 1945–1952): Peter Fickert and Michael TraunerChapter 24.4 Hepatobiliary Trauma (pages 1953–1961): K. Raj Prasad, Patrick A. Coughlin and Giles J. ToogoodChapter 25.1 Surgical Techniques (pages 1963–1983): Peter Neuhaus, Ramon Charco, Josp Fuster Obregon, Constantino Fondevila, Juan Carlos Garcia?Valdecasas, Igal Kam, James Trotter and Gregory T. EversonChapter 25.2 Liver Transplantation: Indications, Contraindications and Results (pages 1984–1995): Gregory T. Everson and Fernando E. MembrenoChapter 25.3 The Perioperative Care and Complications of Liver Transplantation (pages 1996–2002): Mark T. Keegan and David J. PlevakChapter 25.4 Immunosuppression (pages 2003–2009): James NeubergerChapter 25.5 Recurrent Disease and Management in Liver Transplantation (pages 2010–2018): Xavier Forns and Antoni RimolaChapter 25.6 Post?Transplantation Management and Complications (pages 2019–2026): Faouzi Saliba and Didier SamuelChapter 25.7 Liver Transplantation and Quality of Life (pages 2027–2031): Miguel Navasa and Juan RodesChapter 25.8 Emerging Therapies (pages 2032–2052): Govardhana Rao Yannam, Jayanta Roy?Chowdhury, Ira J. Fox, Vanessa Stadlbauer and Rajiv JalanChapter 26.1 Models in Clinical Hepatology (pages 2053–2064): W. Ray KimChapter 26.2 Outcomes Research in Hepatology (pages 2065–2072): Raymond S. KoffChapter 26.3 Meta?Analysis (pages 2073–2079): Gioacchino Leandro and Andrew K. BurroughsChapter 26.4 Economic Considerations in Hepatology (pages 2080–2087): John B. WongChapter 26.5 Development of the Liver Interactome: Mapping the Regulatory Networks (pages 2088–2095): Mario Pagano, Susana Neves, Ravi Iyengar and John Cijiang He