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Evolution-adjusted Tumor Pathophysiology: The Novel Language of Tumor Biology [Repost]
![Evolution-adjusted Tumor Pathophysiology: The Novel Language of Tumor Biology [Repost]](https://pixhost.icu/avaxhome/fa/75/002e75fa.jpeg)
Albrecht Reichle - Evolution-adjusted Tumor Pathophysiology: The Novel Language of Tumor Biology
Published: 2013-07-11 | ISBN: 9400768656, 9400768672 | PDF | 453 pages | 6 MB
Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.