Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches
Margareta Hammarlund-Udenaes, Elizabeth de Lange, Robert G. Thorne - Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches
Published: 2013-12-17 | ISBN: 1461491045 | PDF | 530 pages | 15 MB
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas.