Telomeres: Chromosome Sentinels
Telomeres: Chromosome Sentinels
English | 2024 | ISBN: 1789450977 | 382 Pages | PDF, EPUB (True) | 23 MB
English | 2024 | ISBN: 1789450977 | 382 Pages | PDF, EPUB (True) | 23 MB
The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here.