The calcitonin gene-related peptide family: form, function and future perspectives

This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. This volume includes chapters on: The adrenomedullin peptides and signallingLigand binding and activation of the CGRP receptor Understanding amylin receptors The CGRP-receptor component proteinThe calcitonin peptide familyGenetic regulation of CGRPVascular actions of CGRP and adrenomedullin Intermedin/adrenomedullin 2 functionCGRP and adrenomedullin as pain-related peptidesAmylinergic control of ingestive behaviourCalcitonin receptorsThis book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.