Automation in Proteomics and Genomics: An Engineering Case-Based Approach (Repost)

In the last decade DNA sequencing costs have decreased over amagnitude, largely because of increasing throughput by incrementaladvances in tools, technologies and process improvements. Furthercost reductions in this and in related proteomics technologies areexpected as a result of the development of new high-throughputtechniques and the computational machinery needed to analyze datagenerated.
Automation in Proteomics & Genomics: An EngineeringCase-Based Approach describes the automation technologycurrently in the areas of analysis, design, and integration, aswell as providing basic biology concepts behind proteomics andgenomics. The book also discusses the current technologicallimitations that can be viewed as an emerging market rather than aresearch bottleneck. Topics covered include:
- molecular biology fundamentals: from ‘blueprint’(DNA) to ‘task list’ (RNA) to ‘molecularmachine’ (protein); proteomics methods and technologies;modelling protein networks and interactions
- analysis via automation: DNA sequencing; microarrays and otherparallelization technologies; protein characterization andidentification; protein interaction and gene regulatorynetworks
- design via automation: DNA synthesis; RNA by design; buildingprotein libraries; synthetic networks
- integration: multiple modalities; computational andexperimental methods; trends in automation for genomics andproteomics
- new enabling technologies and future applications
Automation in Proteomics & Genomics: An EngineeringCase-Based Approach is an essential guide to the currentcapabilities and challenges of high-throughput analysis of genesand proteins for bioinformaticians, engineers, chemists, andbiologists interested in developing a cross-disciplineproblem-solving based approach to systems biology.