Nostradamus - The Last Prophecy » is set in 16th century Provence, in a country ravaged by religious wars and devastated by the plague. It has been three years since Catherine de Médicis' rule as regent came to an end, but she still holds the reins of power, making her the target of repeated attacks from the French nobility. One day in March 1566, when she realises that she has fallen victim to a terrible curse, she turns to her doctor and astrologer, Michel de Nostre-Dame, better known as Nostradamus.