Mitochondria and Cell Death

Editors: Hockenbery, David M. (Ed.)
Examines the role of mitochondria in cell death in one comprehensive volume
Discusses current understandings of the underlying mechanisms or cell death
Emphasizes the importance of mitochondrial dysfunction in pathogenesis of clinical diseases to bench-to-bedside investigations

This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.

Number of Illustrations and Tables
3 b/w illustrations, 23 illustrations in colour
Topics
Apoptosis
Membrane Biology
Cell Cycle Analysis

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