"Drosophila melanogaster: Model for Recent Advances in Genetics and Therapeutics" ed. by Farzana Khan Perveen

This book covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics.


The book explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.


Contents
1 Introduction to Drosophila
2 Drosophila Chromosomal Polymorphism: From Population Aspects to Origin Mechanisms of Inversions
3 Cell Cycle Regulators in Female Meiosis of Drosophila melanogaster
4 Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila
5 Drosophila Imaginal Discs as a Playground for Genetic Analysis: Concepts, Techniques and Expectations for Biomedical Research
6 The Fruit Fly, Drosophila melanogaster: The Making of a Model (Part I)
7 The Fruit Fly, Drosophila melanogaster: Modeling of Human Diseases (Part n)
8 Parkinson's Disease: Insights from Drosophila Model
9 Drosophila Model in the Study Role of UCH-L1
10 Swiss Cheese, Drosophila Ortholog of Hereditary Spastic Paraplegia Gene NTE, Maintains Neuromuscular Junction Development and Microtubule Network
11 Substrate Specificities and Kinetic Parameters of Recombinant Drosophila melanogaster Glutathione S-Transferases E6 and E7
12 Antiviral Immunity in the Fruit Fly, Drosophila melanogaster