Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition

The groups of specialized cells that make up the various human tissues depend on an intricate communication network to regulate gene expression that in turn mediates growth, cell-type specific function, division, and programmed cell death. This network consists of extracellular signals interacting with the receptors of individual cells and determining the fate of each. Since this regulatory system plays a critical role in complex tissue, aberrations or malfunctions often accompany the onset and progression of cancer. Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition provides a solid basis for understanding cell cycle and growth control as it relates to biological regulation, with a special emphasis on examining these processes in the context of cancer. Newly updated with the latest significant advances, this Second Edition features: * Cutting-edge applications in clinical diagnostics and therapeutics * Focus on mechanisms mediating the control of proliferation * Numerous clear illustrations * Extensive bibliography * Well-recognized, expert chapter authors * Video clips on accompanying Web site showing cell cycle control Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. The only book to comprehensively cover both the foundations and cutting-edge advances in understanding cell cycle and growth control, this text also contains an expert perspective on innovative strategies for cancer treatment, making it a vital companion for researcher and clinician alike.Content: Chapter 1 Cell Fates (pages 1–13): Arthur B. PardeeChapter 2 Architectural Organization of the Regulatory Machinery for Transcription, Replication, and Repair: Dynamic Temporal?Spatial Parameters of Cell Cycle Control (pages 15–92): Corey D. Braastad, Sayyed K. Zaidi, Martin Montecino, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein and Gary S. SteinChapter 3 Cell Cycle Regulatory Cascades (pages 93–128): Heide L. Ford, Robert A. Sclafani and James DegregoriChapter 4 Membrane Receptors and Signal Transduction Pathways in G1: Regulation of Liver Regeneration and T Cell Proliferation (pages 129–147): Joseph F. Porter and David T. DenhardtChapter 5 Onset of Dna Synthesis and S Phase (pages 149–200): G. Prem?Veer Reddy, Eugenia Cifuentes, Uma Bai, Mani Menon and Evelyn R. BarrackChapter 6 The Progression and Regulation of Mitotic Events (pages 201–235): Greenfield Sluder, Edward H. Hinchcliffe and Conly L. RiederChapter 7 Cell Cycle Inhibitory Proteins (pages 237–264): Carmen Carneiro and Andrew KoffChapter 8 Chromatin Remodeling and Cancer (pages 265–295): Cynthia J. Guidi and Anthony N. ImbalzanoChapter 9 Extracellular Matrix: Tissue?specific Regulator of Cell Proliferation (pages 297–332): Aylin Rizki and Mina J. BissellChapter 10 Angiogenesis and Blood Supply (pages 333–367): Judah FolkmanChapter 11 Regulation of Cell Growth, Differentiation, and Death during Metamorphosis (pages 369–395): Hans Laufer and Eric H. BaehreckeChapter 12 Translational Control and the Cell Cycle (pages 397–448): Robert E. RhoadsChapter 13 Telomere Structure and Function Provides Insights into the Generation of Genomic Instability and Carcinogenesis (pages 449–465): Colleen Fordyce and Thea D. TlstyChapter 14 Immortalization by Sv40 Large T Antigen (pages 467–495): Rowena L. Lock, Silvia Benvenuti and Parmjit S. JatChapter 15 Apoptosis Signaling in Normal and Cancer Cells (pages 497–521): Shulin Wang and Wafik S. El?DeiryChapter 16 Mutagenesis, Mutations, and Dna Repair (pages 523–570): Roger D. JohnsonChapter 17 Oncogenes (pages 571–606): Stacey J. Baker and E. Premkumar ReddyChapter 18 Role of the Retinoblastoma Family in Cell Cycle Progression and Growth Control (pages 607–634): Valeria Masciullo and Antonio GiordanoChapter 19 p53 Tumor?Suppressor Genes (pages 635–666): Faith A. Zamamiri?Davis and Gerard P. ZambettiChapter 20 Cell Cycle and Growth Control: Current Clinical Applications (pages 667–703): Michael DeiningerChapter 21 Misregulated Fate—Cancer (pages 705–771): Arthur B. Pardee