"Metformin" ed. by Anca Pantea Stoian, Manfredi Rizzo

This book aims to bring to light new concepts and trends related to the many metformin therapeutic features.

After a history of over 60 years, with moments of decline and spectacular returns, metformin can now be regarded as a universal panacea, the valences of its therapeutics being increasingly appreciated, both in the background treatment of diabetes and pre-diabetes, but also in reproductive pathology, cancer, cardiovascular disease, and antiageing. In this respect, the mechanisms of action and the pharmacodynamics of metformin seem to be incompletely known, a number of current studies have revealed new action valences.


Contents
1.Metformin Indications, Dosage, Adverse Reactions, and Contraindications
2.New Insight into Metformin Mechanism of Action and Clinical Application
3.Metformin and Its Benefits in Improving Gut Microbiota Disturbances in Diabetes Patients
4.Potential Protective Effects of Metformin on Ocular Complications in Patients with Type 2 Diabetes
5.Galega officinalis L. and Immunological Status in Diabetes Mellitus
6.Metformin in Health Issues and Reproductive System
7.Metformin and Its Implication in Cancer Therapy
8.Preventive and (Neo)Adjuvant Therapeutic Effects of Metformin on Cancer
9.Metformin in Cervical Cancer: Metabolic Reprogramming
10.Antitumoral Effects of Metformin in Ovarian Cancer
11.Metformin Activity against Breast Cancer: Mechanistic Differences by Molecular Subtype and Metabolic Conditions
12.Metformin Modulates the Mechanisms of Ageing